Carbon nanoparticles, with their high biocompatibility and low toxicity, have recently been considered for biomedical applications, including antiangiogenic therapy. Critical to normal development and tumor formation, angiogenesis is the process of forming capillary blood vessels from preexisting vessels. In the present study, we evaluated the effects of diamond and graphite nanoparticles on th...

Introduction ALTHOUGH the cornea normally has no blood vessels, yet, under certain conditions, new vessels freely enter the substa-nce of the cornea from the limbal plexus. To explain this invasion many theories have been advanced. In riboflavin deficiency there is corneal vascularization. Since riboflavin is part of an oxidation enzyme system, Bessey and Wolbach (1939), and Johnson and Eckardt...

In this paper, we present a dynamic Bayesian network (DBN) approach to modeling vascularization in engineered tissues. Injuries and diseases can cause significant tissue loss to the degree where the body is unable to heal itself. Tissue engineering aims to replace the lost tissue through use of stem cells and biomaterials. For tissue cells to multiply and migrate, they need to be close to blood...

In many disorders of the cornea, blood vessels invade this normally avascular tissue. Several theories have been proposed to explain the pathogenesis of corneal vascularization. Since none had received general acceptance, experimental studies of the phenomenon were begun several years ago in hamster cheek pouch chambers. These investigations which employed sequential morphologic studies during ...

In the present study we assessed the potential of human outgrowth endothelial cells (OEC), a subpopulation within endothelial progenitor cell cultures, to support the vascularization of a complex tissue engineered construct for bone. OEC cultured on starch polycaprolactone fiber meshes (SPCL) in monoculture retained their endothelial functionality and responded to angiogenic stimulation by VEGF...

First described in 2004, endometrial stem cells (EnSCs) are adult stem cells isolated from the endometrial tissue. EnSCs comprise of a population of epithelial stem cells, mesenchymal stem cells, and side population stem cells. When secreted in the menstrual blood, they are termed menstrual stem cells or endometrial regenerative cells. Mounting evidence suggests that EnSCs can be utilized in re...

Vessel anastomosis is important in tumor angiogenesis as well as for vascularization therapy for ischemia and other diseases. We report here the development of a color-coded imaging model that can visualize the anastomosis between blood vessels of red fluorescent protein (RFP)-expressing vessels in vascularized Gelfoam® previously transplanted into RFP transgenic mice and then re-transplanted i...

BACKGROUND Metformin has been shown to improve fertility in anovulatory patients with polycystic ovary syndrome (PCOS), inducing not only a high ovulation and pregnancy rate but also reducing the incidence of miscarriages. The aim of the present study was to evaluate the uterine effects of metformin in patients with PCOS who ovulated under metformin. METHODS Thirty-seven non-obese primary inf...

BACKGROUND It has been hypothesised that increased VEGF-D expression may be an independent prognostic factor for endometrial cancer progression and lymph node metastasis; however, the mechanism by which VEGF-D may promote disease progression in women with endometrial cancer has not been investigated. Our aim was to describe the distribution of lymphatic vessels in mouse uterus and to examine th...

background: we conducted our study on 1110 patients with breast masses in order to investigate different aspects of power doppler sonography (pds) for differentiating between benign and malignant breast lesions and their prognostication. materials and methods: this study was conducted on the women who were referred to the sonography units of university hospitals for breast sonography and had a ...