The endoplasmic reticulum undergoes rapid, microscopic changes in its structure, including extension and anastomosis of tubular elements. Such dynamism is expected to manifest itself also as rapid intermixing of membrane components, at least within subdomains of the endoplasmic reticulum. Here we present evidence of a similar dynamism in the sarcoplasmic reticulum of developing skeletal muscle....

The cytoplasm of the rat isolated fat cell contains a highly organized, interconnected system of smooth endoplasmic reticulum having close association with the central lipid mass, mitochondria and cytoplasmic lipid droplets. Elements of smooth endoplasmic reticulum approach, but do not fuse with, the plasma membrane. When fat cells were treated with potassium pyroantimonate during fixation for ...

Objective Recent reports have shown that endoplasmic reticulum stress is associated with cancer. However, the impacts of endoplasmic reticulum stress on the prognosis of lung cancer are unknown. Therefore, in this study, we sought to reveal the relationship between the expression of endoplasmic reticulum stress-related genes (endoplasmic reticulum oxidoreductase 1L, protein kinase RNA-like endo...

BACKGROUND Defects in endoplasmic reticulum homeostasis are common occurrences in different diseases, such as diabetes, in which the function of endoplasmic reticulum is disrupted. It is now well established that ion channels of endoplasmic reticulum membrane have a critical role in endoplasmic reticulum luminal homeostasis. Our previous studies showed the presence of an ATP-sensitive cationic ...

ovine pulmonary adenocarcinoma (opa) was studied in the lungs of 15 naturally-affected sheep (9 with classical and 6 atypical lesions) by transmission electron microscopy. two lung samples from normal sheep were used to develop the ultrastructural criteria. pathologic lesions consisted of focal-multifocal to coalescent nodules or masses in the cranioventral or diaphragmatic lobes. ultrastructur...

The structural differences between  dormant and nondormant seeds of wild oats (Avena ludoviciana Durieu) were studied by light and transmission electron microscopy. Radial elongation of  scutellum epithelial cells were observed in nondormant seeds after imbibition, compared with dormant seeds in which cells were completely compressed. Ultrastructural differences for example, dilution of cytopla...

Canine distemper (CD) caused by canine virus (CDV) is considered a highly contagious and acutely febrile disease in various animals around the world. Endoplasmic reticulum-associated protein degradation (ERAD) an important biological effect induced endoplasmic reticulum (ER) stress (ERS) for of unfolded/misfolded proteins ER cells. CDV H glycoprotein translocated into post-translational modific...

Abstract The endoplasmic reticulum (ER) and mitochondria interact exchange material in healthy neurons. Mutants for the ER protein Creld show strong, Parkinson’s disease-like locomotion deficits. We found that facilitates phospholipid flux at ER-mitochondria interface, thereby enabling formation of hydrogen peroxide respiratory complex I, which is required dopaminergic neuron activity.