Gene Ontology (GO) analysis has become a commonly used approach for functional studies of large-scale genomic or transcriptomic data. Although there have been a lot of software with GO-related analysis functions, new tools are still needed to meet the requirements for data generated by newly developed technologies or for advanced analysis purpose. Here, we present a Gene Ontology Enrichment Ana...

Major depressive disorder (MDD) presents with both peripheral and central alterations, such that crosstalk between the periphery nervous system could contribute to its aetio-pathophysiology. One putative mediating mechanism is circulating extracellular vesicles (EVs) their microRNA (miRNA) cargo. In this study, we investigated differential expression of serum EV miRNome in MDD patients versus c...

Abstract Ear length is an important component of maize grain yield. However, the ear a complex quantitative trait, and underlying molecular mechanisms remain poorly understood. Here, chromosome segment substitution line (CSSL) 1283 displayed longer compared with recipient parent Xu178. An RNA sequencing analysis Xu178 CSSL1283 ears during three undifferentiated developmental stages identified 1...

The mammalian brain is a complex organ composed of many specialized cells, harboring sets of both common, widely distributed, as well as specialized and discretely localized proteins. Here we focus on the human brain, utilizing transcriptomics and public available Human Protein Atlas (HPA) data to analyze brain-enriched (frontal cortex) polyadenylated messenger RNA and long non-coding RNA and g...

Objectives This study aimed to determine the pathophysiology of recurrent benign paroxysmal positional vertigo (BPPV) in young patients using gene expression profiling combined with bioinformatics analysis. Methods Total RNA was extracted from whole blood four BPPV and controls. The differentially expressed genes (DEGs) between groups were screened a microarray analysis based on cutoff criteria...

Abstract Fusarium wilt, caused by the fungus oxysporum Schlecht. f. sp. vasinfectum (Fov) is a destructive soil-borne cotton disease. To profile genes and pathways responding to Fov infection, we compared transcriptomic responses before after F. inoculation in highly resistant cultivar, Yumian21, susceptible Jimian11. Although overall gene expression pattern was downregulated both cultivars, gl...

AimsGestational diabetes mellitus (GDM) is a common complication during pregnancy affecting the mother and fetus. With problems encountered with oral glucose tolerance test (OGTT), we aim to identify potential early biomarkers of GDM.MethodsA cross-sectional study was conducted among 80 pregnant women. Blood samples were collected every trimester, total RNA isolated. After quality control libra...

The present study aimed to identify the underlying molecular mechanisms associated with spinal metastases. Gene expression profiles in cancellous bone samples from the spines of five patients with spinal metastases, with different primary cancers, and three normal control patients were measured using microarray analysis and subsequently compared. The differentially expressed genes (DEGs) identi...