This paper described the efforts of scientists at the National Institute of Environmental Health Sciences (NIEHS) and their allies in the National Toxicology Program to molecularize toxicology by fostering the emergence of a new discipline: toxicogenomics. I demonstrate that the molecularization of toxicology at the NIEHS began in a process of 'co-construction'. However, the subsequent emergenc...

Genetic toxicology is the scientific discipline dealing with the effects of chemical, physical and biological agents on the heredity of living organisms. The Internet offers a wide range of online digital resources for the field of Genetic Toxicology. The history of genetic toxicology and electronic data collections are reviewed. Web-based resources at US National Library of Medicine (NLM), inc...

*Reproductive Toxicology Group, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; ^Department of Toxicology, Crop Protection Division, Ciba-Geigy, Greensboro, North Carolina; ^Comparative Medicine Clinical Research Center, Departments of Comparative Medicine and Obstetrics & Gynecology, The Bowman Gray School of Medic...

toxicology, as a multidisciplinary field, provides career opportunities for graduates with medical, or veterinarian, pharmacological, pharmaceutical, biological, microbiological, molecular biological, chemical, biochemical, and genetic backgrounds. today, however, specialists with a university degree in toxicology or a postgraduate training in toxicology have a clear advantage. postgraduate dip...

1 Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 2 Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA * Corresponding author: B Fadeel, Division of Molecular Toxicology, Institute of Environmental Medicine, Nobels väg 13, Karolinska Institutet, 171 77 Stockholm, Sweden. Tel: þ 46...

ACToR (Aggregated Computational Toxicology Resource) is a database and set of software applications that bring into one central location many types and sources of data on environmental chemicals. Currently, the ACToR chemical database contains information on chemical structure, in vitro bioassays and in vivo toxicology assays derived from more than 150 sources including the U.S. Environmental P...

There is mounting evidence that traditional investigations are no longer sufficient either to assess the ecological characteristics of a resource or to better understand the dynamics of an ecosystem. Reliable experimental data to be used for further investigation as well as for environmental corrective action are obtained using the traditional quantitative and qualitative biological methods. In...