INTRODUCTION Oxidative stress and antioxidants play an important role in the pathogenesis of inflammatory disease, including chronic periodontitis (CP). Saliva contains enzymatic (glutathione peroxidase - GPx, superoxide dismutase - SOD, etc.) and non-enzymatic (albumin - ALB, uric acid - UA, glutathione, etc.) antioxidants. OBJECTIVE The aims of this study were to investigate: a) level of SO...

Drought is an important environmental constraint limiting the productivity of many crops worldwide. Experiments were conducted to investigate the effects of foliar spray of natural extract (garlic extract) on drought stress in two cultivars of soybean (Glycine max) plants. Drought stress caused significant decrease in growth parameters (shoot and root length, area of leaves, fresh and dry weigh...

We have evaluated the ameliorative effect of ginger extract on paraben (p-hydroxybenzoic acid)-induced lipid peroxidation in the liver of mice. Adult female albino mice were orally administered with 2.25 or 4.50 mg of paraben in 0.2 mL olive/animal/day (67.5 and 135 mg/kg of body weight) for 30 days. The results revealed significantly higher (p < or = 0.05) lipid peroxidation in the liver of pa...

The present study was to evaluate the protective role of hesperidin (HDN) against iron-induced hepatic and renal toxicity in rats. Administration of iron (30 mg/kg body weight) intraperitoneally for 10 days, the levels of serum hepatic markers, renal functional markers, lipid profile, lipid peroxidation markers and iron concentration in blood were significantly (p < 0.05) increased. The toxic e...

High level of ROS (Reactive Oxygen Species), due to an increased production of oxidant species and/or a decreased efficacy of antioxidant system, can lead to oxidative stress (OS) an emerging health risk factor involved in the aging and in many diseases, either in humans or in animals. ROS are a double-edged sword – they serve as key signal molecules in physiological processes, but also have a ...

.. Background: Leukemia is a hematological malignancy i.e. that arises in the blood progenitor cells. It is a tumor of white blood cells which is characterized by uncontrolled proliferation of immature hematopoietic WBCs in bone marrow. Leukemia is of two types myeloid and lymphoid and two subtypes acute and chronic. Acute lymphoid leukemia is most common in children. There are certain risk fac...

Cancer has a complex etiology with multiple risk factors that involve the interplay between genetic and environmental influences. There is compelling evidence that dietary plant foods appear to be protective against certain type of cancers. Among a number of mechanistic hypotheses, diet-derived antioxidants have been proposed to contribute to explain these findings. However, contrasting results...

Background:In recent years, the use of chemicals in agriculture, industry, and public health has become so common that the environment is continuously contaminated by the toxic substance-like metals. Aluminum released due to anthropogenic activities such as mining and industrial uses. Aluminium has several industrial uses. The present study was designed to investigate the effect of aluminium ch...

Both artificial and naturally occurring antioxidants have been reported to play major roles in protecting membranes and tissues from free radical and xenobiotic-induced oxidative damage (Burton, 1989; Carini et al., 1990). Most living organisms harbour both enzymatic and non-enzymatic systems that protect them against excessive reactive oxygen species. However, various external factors (smoke, ...

SIGNIFICANCE Antioxidant enzymes are thought to provide critical protection to cells against reactive oxygen species (ROS). However, many organisms can fully compensate for the loss of such enzymatic defenses by accumulating metabolites and Mn²⁺, which can form catalytic Mn-antioxidants. Accumulated metabolites can direct reactivity of Mn²⁺ with superoxide and specifically shield proteins from ...