mucopolysaccharidoses are a group of rare mostly autosomal recessive metabolic and genetic disorders. because of the high rate of consanguinity, they are not uncommon in our population. clinical diagnosis is not difficult for experienced physicians, but it is not enough for treatment and prevention measures in the future pregnancies. so, it is necessary to detect the type of mps by measurement ...

Lipoxygenases (LOXs) have been implicated in cardiovascular disease. A rare single nucleotide polymorphism causing T560M exchange has recently been described and this mutation leads to a near null-variant of the enzyme encoded for by the ALOX15 gene. When we inspected the 3D-structure of the rabbit ortholog we localized T560 outside the active site and identified a hydrogen bridge between its s...

Metabolites can inhibit the enzymes that generate them. To explore the general nature of metabolic self-inhibition, we surveyed enzymological data accrued from a century of experimentation and generated a genome-scale enzyme-inhibition network. Enzyme inhibition is often driven by essential metabolites, affects the majority of biochemical processes, and is executed by a structured network whose...

Abstract Understanding the metabolism mechanisms in living organisms is a major task for postgenomic biology. Cellular metabolism is usually represented by a complex network of reactants connected by chemical reactions catalyzed by enzymes. In this paper, a mass flow conservation model is proposed to describe the process of cellular metabolism, which can be formulated as a linear programming mo...