Retinoblastoma is the most common intraocular malignancy. Its incidence has been reported to be 1 case in from 15 000 18 live births, or approximately 12, 6, 4 cases per million children younger than 5, 10, years, respectively.1,2 The aim of this study was estimate retinoblastoma across European countries within a 1-year time frame. Data were collected through an international, multicenter, cro...

purpose: to report a case of retinocytoma associated with bilateral retinoblastoma. case report: a 3-year-old girl presenting with left eye exotropia was referred to our ophthalmic oncology service for a second opinion. funduscopy under general anesthesia revealed one prominent retinocytoma associated with five discrete retinoblastomas in the left eye and three discrete retino-blastomas in the ...

In spite of recent advances in the treatment of retinoblastoma, chemotherapy is still challenging in high-stage intraocular retinoblastoma or metastatic retinoblastoma. Here, we investigated whether arginine deprivation via arginine deiminase (ADI) could be a new anti-tumor therapy in retinoblastoma cells. Expression of argininosuccinate synthetase (ASS) was detected in human retinoblastoma tis...

PURPOSE To estimate the incidence of trilateral retinoblastoma in patients with retinoblastoma. DESIGN Systematic review and meta-analysis. METHODS We searched Medline and Embase for scientific literature published between January 1966 and July 2015 that assessed trilateral retinoblastoma incidence. We used a random-effects model for the statistical analyses. RESULTS We included 23 retino...

This study analyzes modern views on the history, variants, age at diagnosis of trilateral retinoblastoma, median time from retinoblastoma to trilateral retinoblastoma, the largest size and percentage of trilateral retinoblastoma among retinoblastoma cases, functions of pineal gland, genetics, ocular and intracranial histology, diagnosis, treatment, therapy results, survival rates and frequency ...

purpose: the aim of the present study was to detect the expression of p-glycoprotein (p-gp) and multi-drug resistance associated protein 1 (mrp1) in retinoblastoma tumors, and analyze the relationship between its expression, the clinico-pathological features and recurrence. methods: p-gp and mrp1 expression in formalin-fixed paraffin-embedded retinoblastoma bearing ocular tissue sections from 2...

background: retinoblastoma is the most common embryonic tumor of retina of children. this tumor include 3-4% of all children malignancies during the age range 0-14 years. in this study, we reported the incidence, therapeutic protocols, and treatment outcome of children with rb in south west iran. methods: we retrospectively investigated the medical reports clinical and pathological features of ...

R etinoma is a benign, elevated, gray, translucent retinal mass with cottage cheese–like calcification and hyperpigmented retinal pigment epithelium. Histopathological features includeabundant fleurettes and nonproliferative cells. We report a case in which an underlying retinoma was revealed by collapse and massive vitreous dispersion of the overlying unilateral retinoblastoma after 1 cycle of...

Background/Aim: We investigated the cytotoxic effects of plumbagin on metastatic retinoblastoma, using highly cell line Y79. Materials and Methods: Effect growth was assessed with water-soluble tetrazolium 1 (WST-1) proliferation assay automated hemocytometry trypan blue-exclusion assay. Cell death studied acridine orange/ethidium bromide live-dead annexin-V-fluorescein isothiocyanate/propidium...