Epileptogenic localization is a critical factor for successful epilepsy surgery. Determining the epileptogenic hippocampus with single channel intracranial electroencephalography (iEEG) recording is beneficial to decrease the risk of infection compared with that based on multi-channel iEEGs. Delay permutation entropy (DPE) methodology is presented in this study to measure iEEG with different de...

Despite an abundance of information on clinical and experimental epilepsy and on the drugs effective in its treatment, we 3rc still without a full undentanding of the inherent etiology of the epileptogenic focus and the mechanism of action of anticonvulsant drugs. In recent years allcolion has therefore been mainly directed towards the elucidation of these factors on a neuropharmacological and ...

PURPOSE To evaluate the ability of proton MR spectroscopy to detect metabolic abnormalities in the seizure focus of humans with epilepsy. METHODS Single-voxel MR spectroscopy and MR imaging was performed in a group of 13 patients with a variety of seizure disorders and in the temporal lobes of 14 healthy volunteers. Signals from choline, creatine, N-acetyl-L-aspartate, and lactate were quanti...

The aim of our research is to create algorithms suitable for detecting the presence, localization and determine the extent of epileptogenic focus. We developed experimentally methods for providing view of the diagnostic symptoms. The methods are based on search and evaluation of relations between the monitoring intracranial EEG signals. This paper shows our first approach to the problematic and...

PURPOSE To assess the ability of neuropsychological tests to determine the side of seizure onset for preoperative assessment in patients with drug-resistant temporal lobe epilepsy. METHODS Twenty-nine consecutive patients diagnosed with temporal lobe epilepsy (TLE), in whom the epileptogenic focus was clearly identified and localized to either the right or left hemisphere. Patients underwent ...

UNLABELLED Multiple structural and functional imaging modalities are available to localize the epileptogenic focus. In pre-surgical evaluation of children with pharmacoresistant epilepsy, investigations with the maximum yield should be considered in order to reduce the complexity of the workup. OBJECTIVE To determine the extent to which PET, ictal/interictal SPECT and its co-registration with...

BACKGROUND AND PURPOSE MR imaging, PET, and ictal SPECT have been studied extensively as individual techniques in the localization of epileptogenic foci, but only a few comparative studies have been done. We evaluated the concordance rates of ictal video/EEG, MR imaging, PET, and ictal SPECT to compare the sensitivities of these imaging methods in the lateralization of epileptogenic foci. MET...

We recently reported that epileptic seizures might be facilitated through the action of blood–proteins that leak into the CNS during the chronic epileptic phase in rats (Van Vliet et al., 2007). This was further supported by our mannitol experiments in epileptic rats which showed increased seizure progression in a subgroup of rats. Mannitol can be used to open the blood–brain barrier (BBB) by p...

Functional magnetic resonance imaging (fMRI) triggered by scalp electroencephalography (EEG) recordings has become a promising new tool for noninvasive epileptic focus localization. Studies to date have shown that it can be used safely and that highly localized information can be obtained. So far, no reports using comprehensive clinical information and/or long-term follow-up after epilepsy surg...