Long-lived plasma cells (PCs) and memory B cells (B(mem)) constitute the cellular components of enduring humoral immunity, whereas short-lived PCs that rapidly produce Ig correspond to the host's need for immediate protection against pathogens. In this study we show that the innate affinity of the BCR for Ag imprints upon naive B cells their differentiation fate to become short- or long-lived P...

PURPOSE Ketorolac 0.45% is a new formulation of topical ketorolac in which preservative (benzalkonium chloride, BAK) was removed and carboxymethylcellulose (CMC) was added to improve tolerability and reduce dosing frequency. This study compared the effects of ketorolac 0.45% on corneal wound healing to prior ketorolac formulations (0.4% and 0.5%), bromfenac 0.09%, and nepafenac 0.1%. METHODS ...

The Maximum Entropy Method (MEM) can be used for the reconstruction of the electron density in the unit cell from phased structure factors [1]. The maximum entropy density map ( ) may provide information about disorder and anharmonic temperature movements. If an informative prior density is employed, MEM may be used to derive the electron density in the chemical bond. The MEM can also be applie...

Long-lived memory B cells (B(Mem)) provide an archive of historic Ab responses. By contrast, circulating Abs typically decline once the immunogen is cleared. Consequently, circulating Abs can underestimate the nature of cognate humoral immunity. On the other hand, the B(Mem) pool should provide a comprehensive picture of Ab specificities that arise over the entire course of infection. To test t...

abstract background: improvements in culture media formulations have led to an increase in the ability of sheep embryo in culture throughout the preimplantation period. objective: this study was carried out to evaluate the effects of various concentrations of mem vitamins during in vitro maturation of sheep oocytes and subsequent embryo development. materials and methods: sheep ovaries were col...

PURPOSE To test whether chronic memantine (MEM) treatment improves retinal function and prevents neurodegeneration and vascular changes in the retinas of streptozotocin (STZ)-induced diabetic rats. METHODS Based on basal body weight and blood glucose, Brown Norway (BN) rats were divided into three groups. One group of rats was treated with vehicle (VEH), and the other two groups were treated ...

Despite mounting evidence of disparities in health service provision for migrants and ethnic minorities (MEM) across EU countries, there has been limited research into how services (meso) policy (macro) can contribute to reducing these disparities. In Flemish (Belgian) substance use treatment (SUT) making, no systematic attention is given MEM. Nevertheless, preliminary studies have identified s...

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with unmet medical need, and the leading cause of age-related dementia affecting millions people worldwide. This work aims at developing small, high-drug loading capacity (DL) -entrapment efficiency (EE) memantine hydrochloride (MEM)/chitosan nanocrystals (CS-NCs) to treat moderate severe associated AD. MEM-loaded chitosan (ME...