We present a study designed to measure the average LyC escape fraction ($\langle f_{\rm esc}\rangle$) of star-forming galaxies at z=3.5. assemble sample 148 from VANDELS survey $3.35\leq z_{\rm spec}\leq3.95$, selected minimize line-of-sight contamination their photometry. For this sample, we use ultra-deep, ground-based, $U-$band imaging and HST $V-$band robustly distribution $\mathcal{R_{\rm ...

This report describes the work completed in the Final Year Project “Checking JML Specification Soundness Using ESC/Java2.” It introduces some of the basics of Design by Contract and the Java Modelling Language (JML). This paper primarily deals with the Extended Static Checker ESC/Java2, one of the many powerful tools that understand JML. It describes techniques for extending the functionality o...

Embryonic stem cells (ESC), derived from the early inner cell mass (ICM), are constituted of theoretically homogeneous pluripotent cells. Our study was designed to test this concept using experimental approaches that allowed characterization of progenies derived from single parental mouse ESC. Flow cytometry analysis showed that a fraction of ESC submitted to neural differentiation generates pr...

Mitochondria-targeted compounds are emerging as a new class of drugs that can potentially alter the pathophysiology of those diseases where mitochondrial dysfunction plays a critical role. We have synthesized a novel mitochondria-targeted esculetin (Mito-Esc) with an aim to investigate its effect during oxidative stress-induced endothelial cell death and angiotensin (Ang)-II-induced atheroscler...

• Patients in general and rare disease patients in particular, are in dire need of treatments. They are placing high expectations on ESC research. • Eurordis considers that individuals must have free choice of therapy, and that they should be free to refuse or demand treatments issued from ESC research. • Eurordis is concerned that the current debate could deprive products derived from ESC rese...

BACKGROUND Modelling of cardiac development, physiology and pharmacology by differentiation of embryonic stem cells (ESCs) requires comparability of cardiac differentiation between different ESC lines. To investigate whether the outcome of cardiac differentiation is consistent between different ESC lines, we compared electrophysiological properties of ESC-derived cardiomyocytes (ESC-CMs) of dif...

Pluripotent cells emanate from the inner cell mass (ICM) of the blastocyst and when cultivated under optimal conditions immortalize as embryonic stem cells (ESCs). The fundamental mechanism underlying ESC derivation has, however, remained elusive. Recently, we have devised a highly efficient approach for establishing ESCs, through inhibition of the MEK and TGF-β pathways. This regimen provides ...

To examine the effects of the tat and nef regulatory genes of human immunodeficiency virus (HIV-1) on cell differentiation we used the mouse embryonic stem cells (ESC) as a model. Proliferation, embryoid bodies (EB) formation and subsequent differentiation into cardiomyocytes, glial and neuronal cells were investigated in ESC lines transfected with these genes. It has been shown that the transf...

Numerous studies have focused on the transcriptional signatures that underlie the maintenance of embryonic stem cell (ESC) pluripotency. However, it remains unclear whether ESC retain transcriptional aberrations seen in in vitro cultured embryos. Here we report the first global transcriptional profile comparison between ESC generated from either in vitro cultured or in vivo derived primate embr...

We extended McMillan's Green's function method to study the equilibrium spin current (ESC) in a ferromagnet/ferromagnet (FM/FM) tunnelling junction , in which the magnetic moments in both FM electrodes are not collinear. The single-electron Green's function of the junction system is directly constructed from the elements of the scattering matrix which can be obtained by matching wavefunctions a...