Objective: The images of esophageal carcinoma patients at different clinical stages were studied and the tumor markers Matrix metallopeptidase 9 (MMP-9) and the urinary neutrophil gelatinase-associated lipocalin (NGAL) were analyzed relatively to assess their clinical significance in treatment. Method: 60 esophageal carcinoma patients, who took a cure in our hospital, were selected as the obser...

Esophageal cancer is one of the most fatal diseases worldwide mainly because of its rapid progression and poor prognosis. Although the incidence of esophageal adenocarcinoma has markedly risen in North America and Europe in the past several decades, esophageal squamous cell carcinoma is still the predominant subtype of esophageal cancer, especially in China. It accounts for more than 90% of all...

 Abstract Background: Esophageal cancer is one of the major malignancies, with various epidemiological aspects in recent years in developing countries, including increased prevalence and variations of pathologic patterns. This may be due to increasing rates of Barrett’s esophagus, gastroesophageal reflux, smoking and obesity. This study was performed from 1991 to 2005 in order to evaluate vario...

Despite improvements in surgical techniques, adjuvant chemotherapy and radiotherapy, many patients with esophageal carcinoma still suffer rapid recurrence of the disease and a poor prognosis [1]. Biomarkers should be useful tools to evaluate biological features of esophageal carcinoma to predict recurrence and/or patients’ survival [2]. Basically, thoracic esophageal squamous cell carcinoma (SC...

A bout 7 cases of esophageal carcinoma per 100 000 men are diagnosed in Taiwan, with variable metastatic tendency to other parts of the body. Esophageal carcinoma frequently metastasizes to the lungs and liver, although the metastatic deposits to the bone are infrequent and metastatic disease in the skull is extremely rare. We encountered a patient with a metastasis of esophageal carcinoma over...

BACKGROUND This study was trying to investigate the association of hot food and beverage consumption and the risk of esophageal squamous cell carcinoma in Hotan, a northwest area of China with high risk of esophageal squmous cell carcinoma. METHODS A population-based case-control study was designed. For the study, 167 patients diagnosed with esophageal squamous cell carcinoma were selected fr...

Hypoxia inducible factor 1α (HIF-1α) is highly expressed and is implicated in the progression of esophageal squamous cell carcinoma. To investigate the potential mechanism by which HIF-1α contributes to the progression of esophageal squamous cell carcinoma, here we established stable esophageal carcinoma cell lines Eca-109 and TE- 13 in which HIF-1α was depleted by shRNA mediated gene silencing...

AIMS AND BACKGROUND The role of serum pepsinogen level and Helicobacter pylori infection in esophageal carcinoma remains controversial. It may be a risk or protective factor, or without association with esophageal carcinoma. We prospectively examined associations between serum pepsinogen status, H pylori infection and the risk of esophageal squamous cell carcinoma in the Chinese population. M...

We examined disintegrin and metalloproteinase 17 (ADAM17) protein expression in esophageal squamous cell carcinoma and its clinical and pathological correlated factors. Western blotting and immunohistochemistry were used to detect ADAM17 protein expression in esophageal squamous cell carcinoma and the corresponding normal esophageal mucosa in 50 cases. ADAM17 protein expression in 50 cases with...

Esophageal cancer is a lethal disease with poor survival rate. It is necessary to determine the extension, and the stage of the tumor to predict the outcome of patients. Of the two common pathologic types, squamous cell carcinoma is still the most common form, and adenocarcinoma is the leading one. Early diagnosis and radical treatment of esophageal cancer, regardless of tumor spreading, increa...