OBJECTIVE To study the trends of cancer esophagus in Karachi South during 1995-2002 and identify risk factors. METHODS Incident esophageal cancer cases recorded at the Karachi Cancer Registry for Karachi South, during 1st January 1995 to 31st December 2003 were reviewed. For maximum completion of data, incident cases registered from 1st January 1995 to 31st December 2002 were included for fin...

Abstract Introduction Pharyngeal squamous cell carcinoma is a known risk factor for later of the esophagus. We investigated whether esophageal high enough to justify routine gastroscopy surveillance in northern European population. If among patients with pharyngeal corresponds Barretts esophagus developing adenocarcinoma, it could surveillance. Method Histopathology data from and biopsies obtai...

background: is the third cause of death. the present study aimed at providing the incidence rates (crude and agestandardized)of different types of cancers in sistan and baluchestan province (southeastern of iran).cancer is the second leading cause of death in developing countries. in iran, cancermethodsregistry center of health heputy for sistan and baluchestan province. common cancers weredefi...

INTRODUCTION The prevalence of Barrett's esophagus has been calculated at between 1.3 and 1.6%. There is little information with respect to this in Mexico. AIM To determine the frequency and characteristics of Barrett's esophagus in patients that underwent endoscopy at a national referral center, within a 10-year time frame. MATERIAL AND METHODS The databases of the pathology and gastrointe...

We report of a patient with metastatic adenocarcinoma of the esophagus and stomach from lung cancer. The patient was a 68-year-old man receiving radiotherapy and chemotherapy for stage IV lung cancer, without metastases to the gastrointestinal (GI) tract at the time of the initial diagnosis. During the treatment period, dysphagia and melena newly developed. Upper GI endoscopy revealed geographi...

Glandular dysplasia in Barrett's esophagus may regress spontaneously but can also progress to cancer. The human telomerase RNA template and the human telomerase reverse transcriptase enzyme which do not, of themselves, correlate strongly with telomerase activity, are too often overexpressed in Barrett's dysplasia to predict individual cancer risk. This study relates telomerase activity, mucosal...

BACKGROUND The CDX2 (caudal-related homeobox gene 2) and PITX1 (pituitary homeobox 1) genes have essential roles in human development. Forced expression of Cdx2 alone in the murine stomach results in gastric intestinal metaplasia (IM). This study was undertaken to investigate the expression pattern of these critical morphogenesis genes in the Barrett's multistage carcinogenesis model. METHODS...

Most esophageal adenocarcinomas arise within Barrett's esophagus but the cause of this increasingly prevalent condition remains unknown. Early detection improves survival and discriminant screening markers for Barrett's esophagus and cancer are needed. This study was designed to explore the natural history of eyes absent 4 (EYA4) gene methylation in the neoplastic progression of Barrett's esoph...

Introduction. Cancer of the esophagus ranks sixth in mortality among malignant neoplastic diseases. To understand molecular mechanisms its progression, it is necessary to study not only tumor cells directly, but also microenvironment. In this work, we studied tumor-associated macrophages and their different phenotypes using membrane protein, indoleamine 2,3‑dioxygenase-1 (IDO1) as a marker for ...

Background: is the third cause of death. The present study aimed at providing the incidence rates (crude and agestandardized)of different types of cancers in Sistan and Baluchestan province (Southeastern of Iran).Cancer is the second leading cause of death in developing countries. In Iran, cancerMethodsRegistry Center of Health Heputy for Sistan and Baluchestan province. Common cancers weredefi...