Aldosterone is one of the most essential hormones synthesized by adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) a newly discovered aldosterone receptor, which proposed to mediate non-genomic pathways while hormone simultaneously interacts with mineralocorticoid receptor. In contrast its cardio-protective role in postmenopausal women ...

abstract   background: the iranian breast cancer patients are relatively younger than their western counterparts. evidence suggests that alterations in estrogen signaling pathways , including estrogen receptor-α (er- α ), occur during breast cancer development in caucasians. epidemiologic studies have revealed that age-incidence patterns of breast cancer in asians differ from those in caucasian...

Estrogen-responsive endometrial cancer (EC) is prevalent in uterine cancer. Its precise molecular mechanisms remain to be elucidated partly because of limited availability estrogen-sensitive EC models recapitulating clinical pathophysiology. We previously established patient-derived cell (EC-PDC) spheroid culture with high expression estrogen receptor α (ERα). Using this EC-PDC, we study the tr...

Introduction: Diabetes is associated with an increased risk of cancer. Because of the metastatic nature of cancer, the survival of women with breast cancer is decreasing despite receiving various treatments such as chemotherapy, radiotherapy, etc. The aim of this study was to investigate the relationship between diabetes and the risk factors related to the survival of breast cancer patients. M...

The cover image is based on the Correspondence Dynamic epi-transcriptomic landscape mapping with disease progression in estrogen receptor-positive breast cancer by Stephen Keelan et al., https://doi.org/10.1002/cac2.12407.

10503 Background: Genetic factors that contribute to endogenous estrogen synthesis and postmenopausal breast cancer risk are unknown. We set out test the hypothesis homozygous inheritance of common 1245A→C missense-encoding polymorphism in HSD3B1, which is (8-10%) White populations, functionally adrenal permissive increases aromatase substrate, androstenedione, associated with receptor-positive...

Abstract Emerging studies show that testis-enriched genes play critical roles in several biological processes. The expression of these is tightly regulated and limited to immune-privileged organs; however, many them escape regulation are aberrantly expressed diseases such as cancer. Intriguingly, our genomic analysis revealed transcribed from previously considered gene deserts. We also found a ...

The G protein-coupled estrogen receptor (GPER, nomenclature as agreed by the NC-IUPHAR Subcommittee on [26]) was identified following observations of estrogen-evoked cyclic AMP signalling in breast cancer cells [2], which mirrored differential expression an orphan 7-transmembrane GPR30 [6]. There are both cell-surface and intracellular GPER [29, 34]. Selective agonist/ antagonists for have been...