Osteosarcoma is one of the most malignant bone tumors of childhood and adolescence. Interestingly, the presence of estrogen receptors α and β has been reported in human bone cells, including osteosarcoma. Thus, inhibitors of estrogens such as fulvestrant, are considered candidates for novel endocrine therapy in treatment of osteosarcoma. Another anticancer agent that seems to be very effective ...

OBJECTIVE Our study aims to determine the role of time of menopause on vascular inflammation biomarkers and how it affects their modulation by estrogen and raloxifene in postmenopausal women. METHODS AND RESULTS Uterine arteries from 68 postmenopausal women were divided into 3 segments and cultured for 24 hours in tissue culture media containing 17β-estradiol (100 nmol/L), raloxifene (100 nmo...

Breast cancer is one of the most common malignancies in women around the world. Among the various hormonal types of breast cancer, those that are estrogen receptor (ER) positive account for the majority. Among the estrogen related receptors, estrogen related receptor α is known to have a potential role in breast cancer and is one of the therapeutic target. Hence, prediction of novel ligands int...

objective: estrogen receptor alpha protein status is determined by routine immunohistochemistry analysis in all malignant breast tumors. this assay has its limitations. rna based techniques are potential complements for immunohistochemistry but it must be noticed that gene silencing may occur at different levels from rna to protein. the aim of this study was the comparison of the results from t...