STUDY QUESTION What is the effect of estrogen on heparanase procogulant activity? SUMMARY ANSWER Estrogen increases heparanase procoagulant activity. WHAT IS KNOWN ALREADY Estrogen therapy increases the risk of thrombosis and was previously found to up-regulate heparanase expression. Heparanase is involved in angiogenesis and metastasis, and has been shown to form a complex with tissue fact...

during pregnancy, the need of mother and fetus to iron gradually increases and will reach at its most level at the end of the pregnancy. this study was preformed to evaluate the knowledge and practice of pregnant women in fars province about supplements containing iron intake. data collection was a questionnaire completed by face to face interview using simple nonrandom sampling method in 2997 ...

conclusions it is concluded that dietary supplementation of l-carnitine has no effect on serum levels of estrogen, progesterone and testosterone in cats following ovariohysterectomy. long-term study is recommended. background the benefits of the addition of l-carnitine to the diet of cats to control weight gain after the removal of their ovaries have been highlighted recently. it is also used i...

Pueraria flower extract (PFE) is a hot water extract of the Kudzu flower (Pueraria thomsonii). Tea made from dried Kudzu flower is widely used in China, and PFE is utilized as a nutritional supplement in Japan. PFE contains unique isoflavones such as 6-hydroxygenistein 6,7-di-O-glucoside (6HGDG), tectorigenin 7-O-xylosylglucoside (TGXG), and tectoridin. 6HGDG is known to be metabolized into 6-h...

Aims: Breast and ovarian cancers are frequently associated with mutations in genes involved DNA double-strand break (DSB) repair by homologous recombination (HR). Risk factors for breast cancer often linked to estrogen-related pathways. Here, we studied the crosslink between estrogen HR pathway. Methods: We analyzed, using online annotation tolls, enrichment of candidate estrogen-upregulated am...

Soybean isoflavones have structural similarity to estrogen and have attracted much attention due to their prevention of postmenopausal symptoms. It is critical for women to maintain a high bone mineral density (BMD) prior to menopause to prevent osteoporosis. In the present study, the effect of isoflavone aglycone (IA) supplementation on bone turnover was examined in relation to the estrogen re...

Naturopathic physicians commonly make dietary and/or dietary supplement recommendations for breast cancer prevention. This placebo-controlled, parallel-arm, pilot study tested the effects of two naturopathic interventions over five menstrual cycles on sex steroid hormones and metabolic markers in 40 healthy premenopausal women. The intervention arms were as follows: combination botanical supple...