1. The voluntary ethanol consumption, ethanol elimination rate and blood acetaldehyde level after intraperiotoneal injection of ethanol were studied in rats receiving diets with highly imbalanced proportions of dietary protein, carbohydrate and fat. 2. The rats, which received the low-protein diet containing 0.05 of the total energy as protein, 0.80 as carbohydrate and o.15 as fat, drank only a...

We read with interest the article by Dr. J. V. Ferris reporting his treatment of a patient with polycystic liver disease by serial percutaneous ethanol injection [1]. He mentioned that percutaneous ethanol injection has been considered ineffective in treating extensive polycystic liver disease, resulting in severe symptoms. We report our experience with serial needle aspiration in a patient wit...

introduction: depression has multifactorial characters including brain-behavioral disorders, alteration in cognitive psychomotor and emotional process. millions of people are worldwide suffering from this illness. this disease happens in all ages of men and women. this research tries to introduce a traditional medication in comparison with common chemical anti-depressant drugs. this experiment ...

Fetal alcohol spectrum disorder is associated with defects in neuronal generation, migration, and differentiation. The present study tested the hypothesis that ethanol exposure during the period of naturally occurring neuronal death causes a time- and Bax-dependent neuronal loss. Wild-type and Bax knockout mice were given a pair of injections (two hours apart) of ethanol (2.5 g/kg) or saline on...

We report a case of a man who developed duodenal bleeding caused by direct hepatocellular carcinoma (HCC) invasion, which was successfully treated with endoscopic ethanol injection. A 57-year-old man with known HCC was admitted for melena and exertional dyspnea. He had been diagnosed with inoperable HCC a year ago. Urgent esophagogastroduodenoscopy (EGD) showed two widely eroded mucosal lesions...

 Hepatocellular carcinoma (HCC) is one of the most common malignant tumours in Hong Kong.  Percutaneous ethanol injection (PEI) is an established technique of imaging guided regional therapy for small HCC. In this treatment, absolute ethanol (alcohol) is injected via a small needle into the tumour in an attempt to kill the tumour cells.  The total amount of ethanol injected depends mainly on...

Recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/kainate receptors expressed in oocytes are inhibited by ethanol and the sensitivity to ethanol depends on the kainate concentration and the subunit(s) expressed. For example, GluR3 kainate channels are more sensitive to inhibition by ethanol than GluR6 channels in the presence of maximally effective kainate concentrati...

Executive dysfunction is a common symptom among alcohol-dependent individuals. Phencyclidine (PCP) injection induces dysfunction in the prefrontal cortex of animals but little is known about how PCP affects the response to ethanol. Using the in vivo microdialysis technique in male Wistar rats, we investigated how systemic injection of 5 mg/kg PCP would affect the dopamine release induced by loc...

Cancer side population (SP) cells with cancer stem cell-like properties are thought to be responsible for lung cancer chemotherapy resistance and currently no drug can efficiently target them. Breast cancer resistance protein (BRCP/ABCG2) is a major drug transporter in protecting lung cancer SP cells from cytotoxic agents. We showed that a low concentration of ethanol, which inhibits many membr...