نتایج جستجو برای: etomoxir
تعداد نتایج: 143 فیلتر نتایج به سال:
DIDIER PORTILLA,1 GONGHE DAI,1 JEFFREY M. PETERS,3 FRANK J. GONZALEZ,3 MARK D. CREW,4 AND ALAN D. PROIA2 1Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and John McClellan Memorial Veterans Hospital, Little Rock, Arkansas 72205; 2Department of Pathology, Duke University Medical Center Durham, North Carolina 27710; 3Laboratory of Metabolism, ...
Management of patients with dilated cardiomyopathy (DCM) and chronic heart failure (HF) remains challenging. There is a need for novel medical therapies independent of the neurohormonal axis that improve cardiac performance. Experimental and preliminary clinical studies have demonstrated that metabolic modulators enhancing myocardial glucose metabolism directly or indirectly by limiting free fa...
The mitochondrial outer membrane enzyme carnitine palmitoyltransferase I (CPT I) plays a major role in the regulation of fatty acid entry into the mitochondrial matrix for beta-oxidation by virtue of its inhibition by malonyl-CoA. Two isoforms of CPT I, the liver type (L) and muscle type (M), have been identified, the latter being 100 times more sensitive to malonyl-CoA and having a much higher...
Regulation of fatty acid beta-oxidation (FAO) represents an important mechanism for a sustained balance of energy production/utilization in kidney tissue. To examine the role of stimulated FAO during ischemia, Etomoxir (Eto), clofibrate, and WY-14,643 compounds were given 5 days prior to the induction of ischemia/reperfusion (I/R) injury. Compared with rats administered vehicle, Eto-, clofibrat...
To examine the relationship between mitochondrial energy coupling in skeletal muscle and change in uncoupling protein 3 (UCP3) expression during the transition from the fed to fasted state, we used a novel noninvasive (31)P/(13)C NMR spectroscopic approach to measure the degree of mitochondrial energy coupling in the hind limb muscles of awake rats before and after a 48-h fast. Compared with fe...
Cachexia commonly occurs at the terminal stage of cancer and has largely unclear molecular mechanisms. A recent study published in Nature Medicine, entitled "Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia," reveals that cachectic cancer cells can secrete multiple cytokines that induce excessive fatty acid oxidation, which is responsible for muscle loss in cancer cachex...
Inhibition of brain carnitine palmitoyl-transferase-1 (CPT-1) is reported to decrease food intake and body weight in rats. Yet, the fatty acid synthase (FAS) inhibitor and CPT-1 stimulator C75 produces hypophagia and weight loss when given to rodents intracerebroventricularly (icv). Thus roles and relative contributions of altered brain CPT-1 activity and fatty acid oxidation in these phenomena...
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