836 © 2007 The Authors JEADV 2007, 21, 822–849 Journal compilation © 2007 European Academy of Dermatology and Venereology 5 Hesse S, Berbis P, Privat Y. Keratoderma palmoplantaris papulosa (Bushcke–Fischer’s disease): efficacy of acitretin. Br J Dermatol 1993; 128: 104–105. 6 Horikoshi M, Kuroda K, Tajima S. Puncate palmoplantar keratoderma with pigmentary lesions on the dorsa of feet and ankle...

is characterized by symmetrical hypertrophic plaques, usually located on the pretibial or perimalleolar regions (4, 5). Th e disease has a chronic course, and it is often resistant to treatment. Upon remission, scarring, hypo-or hyperpigmentation may follow (7, 11). Th is paper presents a patient with a giant form of verrucous lichen planus on the lower extremities, with favorable results after...

Lipoid proteinosis (LP) is an extremely rare autosomal recessive genodermatosis, characterized by persistent hoarseness and classical skin lesions. Amorphous hyaline depositions may affect any organ, but mainly the face extremities. These cause limitations in tongue movement, hence, difficulty speaking. Biopsies of lesions usually show massive deposits homogeneous, acidic, hyaline-like material...

Vitamin A (retinol), its metabolites and analogues have been heavily focused upon due to their clinical value and utility. Retinol can be used as a reflection of dietary or nutritional status, while the retinol analogues (isotretinoin, tretinoin, etretinate) are being proven as potent dermatologic and anti-tumor agents. High-performance liquid chromatography (HPLC) has been demonstrated to be a...

Dear Editor, We report the case of a Japanese man with Dari-er's disease (DD) that affected the esophagus as well as the skin. A 49-year-old man, who was diagnosed with DD 19 years earlier, visited us again in October 2008 because his skin lesions had exacerbated. Physical examination revealed reddish-brown crusted fol-licular papules mostly coalesced to produce irregularly shaped warty plaques...