نتایج جستجو برای: eudragit

تعداد نتایج: 828  

2012
Y. M. Jagtap R. K. Bhujbal A. N. Ranade N. S. Ranpise

Floating microspheres have emerged as a potential candidate for gastroretentive drug delivery system. For developing a desired intragastric floatation system employing these microspheres, it is necessary to select an appropriate balance between buoyancy and drug releasing rate. These properties mainly depend on the polymers used in the formulation of the microspheres. Hence it is necessory to s...

2015
DANA HALES MAXIME CASTERAN ANNE SAPIN-MINET IOAN TOMUŢA MARCELA ACHIM LAURIAN VLASE PHILIPPE MAINCENT

BACKGROUND AND AIMS Recent studies have shown that low molecular weight heparins are effective in the treatment of inflammatory bowel disease. Therefore, there is considerable interest in the development of an oral colonic delivery pharmaceutical system allowing targeted release of heparin in the inflamed tissue. The objective of this study was to prepare microparticles for the oral administrat...

2015
Harith Jameel Mahdi

Author’s E-mail: [email protected] Tel:+964-7702660991 In an attempt to combine the favourite properties of hard gelatine capsules with the protective and controlled release properties of enteric coating to get an appropriately and acceptably formulated enteric coated hard gelatine capsules with pH dependent drug release characteristic. Two hard gelatine capsule sizes were selected i.e. siz...

2013

The present study in formulation and evaluation of Mebeverine hydrochloride micropellets. Mebeverine hydrochloride which is used as a anti spasmodic drug to treat irritable bowel syndrome. The pellets were prepared by pan coating powder layering method by using nonpareil seeds in core pellets and were coated with HPMC K4M, Eudragit S100 and Eudragit L100 in different ratios to form a film coat ...

Journal: :Acta pharmaceutica 2005
Yasmin Sultana Mohammad Aqil Asgar Ali

Pefloxacin mesylate is a flouroquinolone antibacterial drug effective in the treatment of bacterial conjunctivitis. The objective of the present work was to develop ocular inserts of pefloxacin mesylate and evaluate their potential for sustained ocular delivery. Reservoir-type ocular inserts were prepared by the film casting technique in teflon coated Petri dishes and characterized in vitro by ...

Journal: :International journal of pharmaceutics 2018
Alison V Keating Jessica Soto Catherine Tuleu Claire Forbes Min Zhao Duncan Q M Craig

Hot melt extrusion has gained considerable attention as a novel technique for taste masking of bitter APIs. The aim of this study was to investigate whether hot melt extrusion could be used to develop taste masked formulations of isoniazid and also to evaluate and correlate different taste assessment methods Two polymers with different physico-chemical properties, Soluplus and Eudragit E-PO wer...

Journal: :European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004
Nathalie Huyghebaert An Vermeire Jean Paul Remon

The aim of this study was to develop an alternative method for enteric coating of HPMC capsules that avoids the sealing step before coating, resulting in ready-to-use enteric-coated capsules for the use in retail or hospital pharmacy or R&D sections of pharmaceutical industry and for the production of enteric-coated heat and moisture sensitive biomaterials. HPMC caps and bodies 00 (Vcaps, Capsu...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2006
Mamoru Fukuda Nicholas A Peppas James W McGinity

The purpose of this study was to investigate the influence of sodium bicarbonate on the physicochemical properties of controlled release hot-melt extruded (HME) tablets containing Eudragit RS PO and/or Eudragit E PO. Acetohydroxamic acid and chlorpheniramine maleate were used as model drugs. Sodium bicarbonate was incorporated into the tablet formulations and the drug release properties and buo...

2008
Yvonne Tan Tze Fung

The prolonged release gliclazide matrix tablets were prepared using polymeric materials, namely, HPMC, Kollidon SR, Carbopol with Xanthan gum, Eudragit RSPO and Eudragit RLPO. HPMC, Kollidon SR and Carbopol with Xanthan gum were able to retard gliclazide release from matrix tablets in a concentration dependent manner, but the rate of retardation differed among the polymers. On the other hand, d...

Journal: :International journal of pharmaceutics 2011
Xue-qing Wang Jie-ming Fan Ya-ou Liu Bo Zhao Zeng-rong Jia Qiang Zhang

Sorafenib is slightly absorbed in the gastrointestinal tract due to its poor solubility in water. To improve its absorption, a novel nanoparticulate formulation-nanomatrix was used in the study. The nanomatrix was a system prepared from a porous material Sylysia(®) 350 and a pH sensitive polymer Eudragit(®). The formulations were optimized by orthogonal design (L(9)(3(4))) and their bioavailabi...

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