This is a comment on “New insights into the Steen solution properties: breakthrough in antioxidant effects via NOX2 downregulation” [1]. The addressed paper investigated reactive oxygen species (ROS) production and NADPH oxidase (NOX2) activity in platelets, polymorphonuclear leukocytes, and lymphocytesmonocytes, while being incubated in buffer solution and in Steen solution. The results showed...

TO THE EDITOR: The stop of flow (ischemia) would be interpreted as membrane depolarization, through the inhibition of KATP channels, leading to activation of NADPH oxidase, leading to increased reactive oxygen species (ROS) production (1). The resultant ROS are claimed to be an effective mediator for ischemic preconditioning (IPC), as proved by the observation that the presence of antioxidants ...

Ex vivo lung perfusion (EVLP) is probably the most promising technique currently available to substantially increase the number of acceptable donor lungs and to improve the outcome after lung transplantation. Several ongoing prospective single and multicentre trials are currently investigating the potential and the individual advantages of different platforms available for EVLP. So far, a numbe...

Lung transplantation (LTx) remains the only therapeutic strategy for the treatment of end-stage respiratory failure in selected patients [1,2]. However, clinical scenario of LTx is rapidly changing. Two aspects still characterize LTx in comparison with the transplant of other solid organs. First, only a limited number of lung grafts is considered suitable for transplant within the donors’ pool....

OBJECTIVE Lung transplantation is hampered by the lack of organs resulting in deaths on the waiting list. The usage of donation after circulatory death (DCD) lungs would dramatically increase donor availability. The most optimal organ preservation method, and the need for antithrombotic and fibrinolytic treatment to prevent thrombosis in the donor lungs is currently on debate. The present study...

PurposeCurrent commercially available EVLP solutions are designed to mimic physiological conditions support donor lungs outside of the human body. These have been effective at offering for donated after brain death but they limited in their ability cardiac death. To characterize hemodynamics utilizing altered purpose enhancing lung viability, a research device was devised.MethodsThe (fig. 1) is...

OBJECTIVES Non-heart-beating donation (NHBD) has the potential to increase the number of patients treated with lung transplantation. Our study investigated, in a simulated clinical situation in the uncontrolled NHBD setting, whether or not heparin administration after death affects the donor lung function. METHODS Twelve Swedish domestic pigs underwent ventricular fibrillation and were left u...