Brain cephalin (1) has been the name given to a fraction of brain phosphatides characterized by its solubility in ether and insolubility in ethyl alcohol. For many years it was assumed to be a single compound with the chemical structure of diacylglycerylphosphoryl ethanolamine. Work from this laboratory has shown brain cephalin to be a mixture (2). From it were separated two pure phosphatides; ...

Phospholipids of Tenebrio molitor larvae were separated on columns of DEAE -cellulose and silicic acidHyflo Super Cel. The major phosphatide components were identified by various analytical procedures. Phosphatidyl choline was demonstrated to be the predominant phospholipid with a high percentage of phosphatidyl ethanolamine. A small amount of inositolcontaining phosphatides were present. Phosp...

The fatty acid composition of wheat seedling roots changed in response to temperature. As temperature declined, the level of linolenic acid increased and the level of linoleic acid decreased. The distribution of phospholipid classes was not influenced by temperature. Phosphatidyl choline and phosphatidyl ethanolamine were the predominant phospholipids isolated and comprised 85% of the total lip...

Lipid nanocapsules (LNC) based on a core-shell structure consisting of an oil-filled core with a surrounding polymer layer are known to be promising vehicles for the delivery of hydrophobic drugs in the new therapeutic strategies in anti-cancer treatments. The present work has been designed as basic research about different LNC systems. We have synthesized-and physico-chemically characterized-t...

Total lipid extracted from wild-type Trichophyton terrestre CDC-X285 was found to be 2.0 percent of the dry cell weight. The total lipid contained the following phospholipid components identified by silicic acid-impregnated thin-layer and paper chromatography: phosphatidyl inositol, phosphatidyl choline, phosphatidyl serine, and phosphatidic acid. The total lipid extracted from the phenotype T....

Xanthomonas bacterium exhibited post-exponential programmed cell death (PCD) under certain nutritional conditions especially in a protein rich medium. PCD was not displayed by Xanthomonas cells while growing in minimal medium like starch minimal medium or M9 medium. While undergoing PCD, the organism was found to transform to spherical membranous apoptotic body like structures. The transformati...

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease that is characterized by a particularly marked resistance to chemotherapy. We previously showed an association between decreased expression of BNIP3 and chemoresistance in PDAC cell lines. To further explore the molecular basis of chemoresistance in PDAC, we analyzed microarray data obtained from normal pancreas and PDAC tumor sam...

We report mechanism-based evidence for the anticancer and chemopreventive efficacy of [6]-gingerol, the major active principle of the medicinal plant, Ginger (Zingiber officinale), in colon cancer cells. The compound was evaluated in two human colon cancer cell lines for its cytotoxic effect and the most sensitive cell line, SW-480, was selected for the mechanistic evaluation of its anticancer ...

The growth and survival of intracellular parasites depends on the availability of extracellular nutrients. Deprivation of nutrients viz glucose or amino acid alters redox balance in mammalian cells as well as some lower organisms. To further understand the relationship, the mechanistic role of L-arginine in regulation of redox mediated survival of Leishmania donovani promastigotes was investiga...

Nanotized phytochemicals are being explored by researchers for promoting their uptake and effectiveness at lower concentrations. In this study, O-hexadecyl-dextran entrapped berberine chloride nanoparticles (BC-HDD NPs) were prepared, and evaluated for their cytoprotective efficacy in high glucose stressed primary hepatocytes and the results obtained compared with bulk berberine chloride (BBR) ...