We have identified and mapped three members of a new family of vertebrate genes, designated Eya1, Eya2 and Eya3, which share high sequence similarity with the Drosophila eyes absent (eya) gene. Comparison of all three murine Eya gene products and that encoded by the Drosophila eya gene defines a 271 amino acid carboxyl terminal Eya domain, which has been highly conserved during evolution. Eya1 ...

10.1128/MCB.24.14.6253-6267.2004. 2004, 24(14):6253. DOI: Mol. Cell. Biol. Pascal Maire Petrof, Dominique Daegelen, Jean-Paul Concordet and Kiyoshi Kawakami, Pin-Xian Xu, Robert Kelly, Basil J. Lopez, Josiane Demignon, Jacques-Emmanuel Guidotti, Raphaelle Grifone, Christine Laclef, François Spitz, Soledad Phenotype into the Fast-Twitch Phenotype Adult Muscle from the Slow-Twitch Six1 and Eya1 E...

The inner ear develops from a simple epithelial vesicle that gives rise to the sensory hair cells, neuroblasts, secretory cells and other non-sensory tissue of the inner ear. In the zebrafish embryo, sensory hair cells begin to differentiate at the anterior and posterior ends of the otic vesicle, forming two distinct and separate sensory patches or maculae. Otic neuroblasts arise from an antero...

This article criticises current BoP approaches for under-appreciating two issues that play vital roles in projects targeting the poor at the BoP: heterogeneity among the poor, and the intricacies of participatory partnerships between TNCs, the non-profit sector (NGOs) and local poor communities in the global south. Our main contention is that the extant BoP literature has a naïve view of what w...

The inner ear develops from a simple epithelial vesicle that gives rise to the sensory hair cells, neuroblasts, secretory cells and other non-sensory tissue of the inner ear. In the zebrafish embryo, sensory hair cells begin to differentiate at the anterior and posterior ends of the otic vesicle, forming two distinct and separate sensory patches or maculae. Otic neuroblasts arise from an antero...

The journal is retracting ‘Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium’ by Ahmed H. K. ElHashash, Gianluca Turcatel, Saaket Varma, Mohamed Berika, Denise Al Alam and David Warburton (2012). J. Cell Sci. 125, 4036-4048 (doi: 10.1242/102848). Journal of Cell Science is retracting this article at the request of the institution. The authors have been notifi...

The developmental processes leading to the differentiation of mechanosensory hair cells and statoacoustic ganglion neurons from the early otic epithelium remain unclear. Possible candidates include members of the Pax-Six-Eya-Dach (paired box-sine oculis homeobox-eyes absent-dachshund) gene regulatory network. We cloned zebrafish six1 and studied its function in inner ear development. Gain- and ...

MLL encodes a histone methyltransferase that is critical in maintaining gene expression during embryonic development and hematopoiesis. 11q23 translocations result in the formation of chimeric MLL fusion proteins that act as potent drivers of acute leukemia. However, it remains unclear what portion of the leukemic genome is under the direct control of MLL fusions. By comparing patient-derived l...

In pre-mRNA splicing, a conserved AG/G at the 3'-splice site is recognized by U2AF(35). A disease-causing mutation abrogating the G nucleotide at the first position of an exon (E(+1)) causes exon skipping in GH1, FECH and EYA1, but not in LPL or HEXA. Knockdown of U2AF(35) enhanced exon skipping in GH1 and FECH. RNA-EMSA revealed that wild-type FECH requires U2AF(35) but wild-type LPL does not....