Acute myeloid leukemia (AML) is a heterogeneous disease with respect to biology and clinical course. Until now the basis for prognostic evaluation and therapeutic decision has been the karyotype, genetic FLT3 abnormalities and the initial chemotherapy response. A question that has emerged is if extensive gene expression analysis may supplement or partly replace current diagnostics. In an attemp...

We compared the immunophenotypic and karyotypic features of 25 cases of minimally differentiated acute myeloid leukemia (AML-M0) with those of 247 cases comprising all AML French-American-British (FAB) classification. Myeloperoxidase (MPO) was detectable with a specific monoclonal antibody in all cases of AML-M0, whereas CD13 and CD33 were both negative in 4 of the 25 cases. Thus, anti-MPO reli...

BACKGROUND The MDS-IWG and NCCN currently endorse both FAB and WHO classifications of MDS and AML, thus allowing patients with 20-30 % bone marrow blasts (AML20-30, formerly MDS-RAEB-t) to be categorised and treated as either MDS or AML. In addition, an artificial distinction between AML20-30 and AML30+ was made by regulatory agencies by initially restricting approval of azacitidine to AML20-30...

The perspective of the classification of any disease is to treat them according to their biologic behavior. Standard criteria to distinguish between myeloid and lymphoid acute leukemias were laid down as the first of its kind, by the French-American-British (FAB) working group. The FAB classification had a cursory correlation with clinical outcome, poor concordance owing to inter-observer varia...

OBJECTIVE: To determine the frequency of proptosis and associations with demographic, clinical hematological characteristics acute myeloid leukemia (AML) in children. METHODS: This descriptive study was conducted at Combined Military Hospital, Rawalpindi, Pakistan from January 2018 to July 2020. Patients AML between 1-12 years age who presented without orbital granulocytic sarcomas (OGS), selec...

An automatic defect classification (ADC) system for visual inspection of semiconductor wafers, using a neural network classifier is introduced. The proposed Hyperellipsoid Clustering Network (HCN) employing a Radial Basis Function (RBF) in the hidden layer, is trained with additional penalty conditions for recognizing unfamiliar inputs as originating from an unknown defect class. Also, by using...

ALL is now diagnosed and classified according to the WHO classification of neoplastic disease of hematopoietic and lymphoid tissues [2]. ALL is defined by the presence of ≥ 20% lymphoblasts in the marrow or peripheral blood. This is a change from the previous FAB classification, which required ≥ 30% blasts [3]. The relationship between ALL and lymphoblastic lymphoma remains unclear. Under the W...

Pediatric mixed-lineage leukemia (MLL)-rearranged acute monoblastic leukemia with t(9;11)(p22;q23) has a favorable outcome compared with other MLL-rearranged AML. The biologic background for this difference remains unknown. Therefore, we compared gene expression profiles (GEPs; Affymetrix HGU133 + 2.0) of 26 t(9;11)(p22;q23) patients with 42 other MLL-rearranged AML patients to identify differe...

This study focuses on fabrication laboratories (fab labs) that provide user-oriented innovative urban spaces to meet advanced technologies and city dwellers who can share their knowledge in solving local problems. The aim is explore the potential of fab labs as a part smart initiatives develop by creating network for collective technology-enabled production collaboration with communities, compa...