factor v (fv) deficiency is a rare bleeding disorder (rbd) that inherit in autosomal recessive manner. diagnosis of fv deficiency (fvd) is made by routine coagulation tests, fv activity and molecular analysis. in patients with fvd, routine coagulation tests including activated partial thromboplastin time (aptt), prothrombin time (pt) and evenbleeding time (bt) are prolongedwhile thrombin time (...

stroke, though rare in children is among the top 10 causes of death in childhood. incidence of ischemic and hemorrhagic stroke is the same in children .we report a case of hemorrhagic stroke in a two year old girl who presented with a limp, inability to stand on the left leg and left hemiparesia. her complaint began 10 days ago after a bout of left clonic seizure. she had been admitted to the h...

Factor X deficiency is a rare hereditary coagulation disorder. We report a case of congenital factor X deficiency diagnosed preoperatively in an 8-yr-old female child scheduled to undergo corrective surgery for congenital thoracolumbar kyphoscoliosis. Her preoperative coagulation profile revealed prolonged prothrombin time and activated partial thromboplastin time values. Further evaluation sho...

background: iran has a large group of patients with severe congenital factor xiii deficiency (fxiiid) and trp187arg mutation that is most disease causing mutation of fxiii in the world is only observed in southeast of iran with 352 patients with fxiiid. 743 patients with fxiiid was observed in 17 provinces of iran but tehran city with more than 12 million population has no any registered patien...

C OAGULATION DEFECTS due to the lack of a single blood clotting factor are almost exclusively congenital and symptoms appear in early life. Acquired defects other than iatrogenic are usually the result of liver dysfunction and in such cases more than one clotting factor is depressed. A case of selective factor X deficiency developing in middle life and associated with extensive amyloidosis has ...

Factor X deficiency is a severe rare hemorrhagic condition inherited as an autosomal recessive trait. It is one of the most severe recessive inherited coagulation disorders. We analyzed the clinical manifestations, laboratory phenotype and genotype in 10 patients with severe Factor X deficiency and in their heterozygous relatives. The most frequent bleeding episodes were hematomas (70%) and gum...

Factor X deficiency (also known as Stuart-Prower factor deficiency) is an extremely rare hereditary hematologic disorder, affecting 1 person in 2 million. The gene causing this condition is autosomal recessive; thus, only those inheriting from both parents exhibit clinical symptoms, such as moderate bleeding, easy bruising and subcutaneous bleeding from mucous membranes. Patients with marked de...

C OAGULATION DEFECTS due to the lack of a single blood clotting factor are almost exclusively congenital and symptoms appear in early life. Acquired defects other than iatrogenic are usually the result of liver dysfunction and in such cases more than one clotting factor is depressed. A case of selective factor X deficiency developing in middle life and associated with extensive amyloidosis has ...