Pulmonary hypertension (PH) is a progressive and often fatal disorder whose pathogenesis involves pulmonary artery smooth muscle cell (PASMC) proliferation. Although modern PH therapies have significantly improved survival, continued progress rests on the discovery of novel therapies and molecular targets. MicroRNA (miR)-21 has emerged as an important non-coding RNA that contributes to PH patho...

objective(s): hypoxia is a serious challenge for treatment of solid tumors. this condition has been manifested to exert significant therapeutic effects on glioblastoma multiform or (who) astrocytoma grade iv. hypoxia contributes numerous changes in cellular mechanisms such as angiogenesis, metastasis and apoptosis evasion. furthermore, in molecular level, hypoxia can cause induction of dna brea...

introduction: pro-inflammatory chemokines and cytokines   such as mcp-1 and il6 can activate microglial cells that has found in some neuro-inflammatory disorders. hypoxia activates cerebral endothelial cells to release these pro-inflammatory mediators. we aimed to investigate the anti-hypoxic effects of different doses of some gabaergic agents. materials and methods: we randomly divided 150 mic...

Background: Due to the importance of industrial accidents in workplaces, the current study aimed at epidemiologically investigating occupational accidents in some industrial sites in Semnan, Iran. Materials and Methods: The current descriptive-analytical study was conducted on all accidents taking place from 2014 to 2016 in some industrial sites in Semnan. The data were extracted from the Depa...

Objective(s): Impairment of nerve cells of brain induced by hypoxia results in energy-deprivation and dysfunction, which accompanies with neurons apoptosis. Improving function of nerve cells is important for treating cerebral anoxia. This study aimed to investigate the role of Quercetin (Quer) in hypoxia-induced injury of pheochromocytoma (PC-12) cells. Materials and Methods: PC-12 cells were c...

Coronavirus disease (COVID-19), caused by Sars-Cov-2, affects several cell types, including the vascular endothelium, which can lead to immunological phenomena and coagulopathies with systemic lesions. Thus, objective was describe, through a bibliographic review, endothelial dysfunction induced coronavirus. The data collected in this study suggest that lesion of endothelium coronavirus leads de...

mouth breathing might not always result in hypoxia, but can contribute to it. the aim of the present study was to determine the effect of mouth breathing on hypoxia. based on a pilot study, 323 patients with mouth breathing were selected. assessment of mouth breathing was based on clinical examination and questionnaires filled out by patients and their companions. the patients were also examine...

The choking game is defined as a self-strangulation or strangulation by another person with the hands or a noose to achieve a brief euphoric state caused by cerebral hypoxia. Death may occur, but forensic pathologists often classify them as suicides or accidental deaths, without focusing on the possibility that they may result from a deliberate self-temporary-asphyxiation, turned into a deadly ...

When pulmonary hypertension (PH) develops in a patient with idiopathic pulmonary fibrosis (IPF) it is usually categorised in World Health Organization (WHO) group III: PH associated with chronic lung disease and/or hypoxia [1]. Given the fact that pulmonary arterial hypertension (PAH) (WHO group I) and IPF are both rare and fatal diseases, their manifestation in a single patient is unlikely to ...