Although clinical observations suggest that humans with amygdala damage have abnormal fear reactions and a reduced experience of fear, these impressions have not been systematically investigated. To address this gap, we conducted a new study in a rare human patient, SM, who has focal bilateral amygdala lesions. To provoke fear in SM, we exposed her to live snakes and spiders, took her on a tour...

Williams syndrome (WS) is a genetic condition often paired with abnormal social functioning and behavior. In particular, those with WS are characterized as being relatively hypersocial, overly emotional/empathic, and socially uninhibited or fearless. In addition, WS is associated with abnormal amygdala structure and function. Very little is known however about the relationship between specific ...

We review recent work on the role of intrinsic amygdala networks in the regulation of classically conditioned defensive behaviors, commonly known as conditioned fear. These new developments highlight how conditioned fear depends on far more complex networks than initially envisioned. Indeed, multiple parallel inhibitory and excitatory circuits are differentially recruited during the expression ...

background: fear of falling is common amongst older adults, especially those who live in nursing homes. this study aimed to determinate factors associated with fear of falling and functional independence in older adults living in nursing homes. methods: this was a cross-sectional study using a convenience sampling method to enroll 200 older adults living in nursing homes from 25 senior centers ...

This writing is the product of an investigation that in its first stage and purpose to analyze how certain phenomena social reality impact lives boys girls, generating fear, which implies violation their rights. Thus, from this phenomenon, it necessary identify elements affect construction fear provide tools transform situation, so they are used peace coexistence. To develop phase study, applie...

objective: it seems that emotion regulation strategies and fear of positive evaluation are among psychological components. which play critical role in anxiety disorders. the present study predicted school anxiety based on emotion regulation strategies and fear of positive evaluation in female students in savadkouh iran.  methods: this study is a descriptive-correlative research. a total of 110 ...

Throughout the history of psychopathology, several meanings have been assigned to the term melancholia. The main ones were related to affective disorders (fear and sadness) and abnormal beliefs. At the time of Hippocrates melancholia was regarded mainly in its affective component. Since that time, and until the eighteenth century, authors and opinions have been divided, with both aspects (affec...

To study the neuronal deficits in neuronopathic Gaucher Disease (nGD), the chronological behavioral profiles and the age of onset of brain abnormalities were characterized in a chronic nGD mouse model (9V/null). Progressive accumulation of glucosylceramide (GC) and glucosylsphingosine (GS) in the brain of 9V/null mice were observed at as early as 6 and 3 months of age for GC and GS, respectivel...

Hypothyroidism is the most common hormonal disease in adults, which is frequently accompanied by learning and memory impairments and emotional disorders. However, the deleterious effects of thyroid hormones deficiency on emotional memory are poorly understood and often underestimated. To evaluate the consequences of hypothyroidism on emotional learning and memory, we have performed a classical ...

fear of crime is a very prevalent issue today. it challenges the safety of cities. for this reason it has gained considerable attention among the sociologists and criminologists over the last 20 years. whilst men experiencing relatively high rates of violence, they report their fear of crime less than women. in the contrary women have a much greater fear of crime than men, but are victimized le...