نتایج جستجو برای: feeder free condition

تعداد نتایج: 816016  

2009
Mark Denham Jessie Leung Cheryl Tay Raymond C.B. Wong Peter Donovan Mirella Dottori Alice Pébay

The optimal maintenance of human embryonic stem cells (hESC) in vitro is generally observed in the presence of a feeder-layer of mouse embryonic fibroblasts in a serum-containing medium. Various approaches are now available to remove the feeder requirement. Today, the best feeder-free system for the maintenance of hESC and induced pluripotent stem (iPS) cells is based on a serum-replacement med...

2015
Ibon Garitaonandia Hadar Amir Francesca Sesillo Boscolo Gerald K. Wambua Heather L. Schultheisz Karen Sabatini Robert Morey Shannon Waltz Yu-Chieh Wang Ha Tran Trevor R. Leonardo Kristopher Nazor Ileana Slavin Candace Lynch Yingchun Li Ronald Coleman Irene Gallego Romero Gulsah Altun David Reynolds Stephen Dalton Mana Parast Jeanne F. Loring Louise C. Laurent

The self-renewal and differentiation capacities of human pluripotent stem cells (hPSCs) make them a promising source of material for cell transplantation therapy, drug development, and studies of cellular differentiation and development. However, the large numbers of cells necessary for many of these applications require extensive expansion of hPSC cultures, a process that has been associated w...

2009
Yumi Kawahara Tomotaka Manabe Masaya Matsumoto Teruyuki Kajiume Masayasu Matsumoto Louis Yuge

BACKGROUND Leukemia inhibitory factor (LIF) is an indispensable factor for maintaining mouse embryonic stem (ES) cell pluripotency. A feeder layer and serum are also needed to maintain an undifferentiated state, however, such animal derived materials need to be eliminated for clinical applications. Therefore, a more reliable ES cell culture technique is required. METHODOLOGY/PRINCIPAL FINDING...

2014
Yuki Hasegawa Dave Tang Naoko Takahashi Yoshihide Hayashizaki Alistair R. R. Forrest the FANTOM consortium Harukazu Suzuki

In the Abstract: ‘‘Further, we show that hiPSCs cultured with CCL2 can differentiate at a higher efficiency than culturing with just bFGF and we show CCL2 can be used in feeder-free conditions in the absence of LIF’’ should read ‘‘Further, we show that hiPSCs cultured withCCL2 can differentiate at a higher efficiency than culturing with just bFGF and we show CCL2 can be used in feeder-free cond...

Journal: :Folia biologica 2014
P Šimara L Tesařová S Padourová I Koutná

Preclinical studies have demonstrated the promising potential of human induced pluripotent stem cells (hiPSCs) for clinical application. To fulfil this goal, efficient and safe methods to generate them must be established. Various reprogramming techniques were presented during seven years of hiPSCs research. Genome non-integrating and completely xeno-free protocols from the first biopsy to stab...

2014
Puladasu Sudhakar

This paper mainly deals the impact of relays on feeder protection also different factors used to control the active power, reactive power, power reversals, fault current magnitude and balancing condition of power system to protect the distribution system. when Distributed Generation sources are integrated in to the grid above all problems are occurs along with the feeder voltage regulation and ...

2016
Zhenqiang Zhao Yanlin Ma Zhibin Chen Qian Liu Qi Li Deyan Kong Kunxiong Yuan Lan Hu Tan Wang Xiaowu Chen Yanan Peng Weimin Jiang Yanhong Yu Xinfeng Liu

Mouse embryonic fibroblasts (MEFs) and human foreskin fibroblasts (HFFs) are used for the culture of human embryonic stem cells (hESCs). MEFs and HFFs differed in their capacity to support the proliferation and pluripotency of hESCs and could affect cardiac differentiation potential of hESCs. The aim of this study was to evaluate the effect of MEFs and HFFs feeders on dopaminergic differentiati...

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