Background : Hepatitis B virus (HBV) is a non-cytopathic virus, and the hepatocellular injury that occurs as a consequence of HBV infection is mediated by the host antiviral immune response. Subjects with natural tolerance to HBV have minimal or no liver injury despite chronic viremia. We have shown that immune tolerance towards viruses can be induced by oral administration of viral proteins. A...

In this paper, fault-tolerant MPC control of PEM fuel cells is addressed. MPC is a suitable control methodology to control fuel cell systems because of their multivariable and complex behaviour. Additionally, MPC is one of the control methodologies that can introduce more easily fault-tolerance. However, the problem of including actuator fault-tolerance in the control loops of these systems has...

Oral tolerance prevents oral sensitization to dietary antigens (Ags), including proteins and haptens, and development of delayed-type hypersensitivity (DTH) responses. We showed here that plasmacytoid dendritic cells (pDCs) prevented oral T cell priming and were responsible for systemic tolerance to CD4(+) and CD8(+) T cell-mediated DTH responses induced by Ag feeding. Systemic depletion of pDC...

background: feeding intolerance is prevalent in very low birth weight (vlbw) neonates and is a barrier for better and faster growth in these neonates. some studies have supported the administration of oral probiotic to decrease feeding intolerance. the aim of this study was to evaluate the effect of probiotic on feeding intolerance in vlbw neonates. methods: this randomized clinical trial study...

OBJECTIVE This prospective randomized clinical study was conducted to evaluate the safety and tolerability of early oral feeding after colorectal operations. METHODS A total of 199 patients underwent colorectal surgery and were randomly assigned to early feeding (n = 99) or a regular diet (n = 100). Patients' characteristics, diagnoses, surgical procedures, comorbidity, bowel movements, defec...

BACKGROUND Chronic dietary restriction (DR) has been shown to have beneficial effects on glucose homeostasis and insulin sensitivity. These factors show rapid and robust improvements when rodents were crossed over from an ad libitum (AL) diet to DR in mid life. We aimed to determine whether the beneficial effects induced by short-term exposure to DR can be retained as a 'metabolic memory' when ...

Background Early dietary introduction of peanut has shown efficacy in clinical trials and driven pediatric recommendations for early to children with heightened allergy risk worldwide. Unfortunately, tolerance is not induced every case, a subset patients are allergic prior introduction. Here we assess sensitization oral genetically diverse mouse strains. Objective We aimed determine whether env...

Mast cell activation in response to food allergens can result in symptoms such as anaphylaxis. It is unclear how this activation impacts on the immune response to other foods that are present. The objective of this study was to investigate the role of immunoglobulin E (IgE)-mediated mast cell activation in the regulation of oral tolerance to a food antigen using a mouse model. Oral tolerance to...