This study is aimed at investigating the effects of tamoxifen on lipid profile. In order to achieve this, was administered once daily intraperitoneally female rats a dose 2.07mg/kg body weight for 1 and 2 weeks, while group allowed recover week after weeks administration. Rats in control were similarly treated but given corn oil instead drug. Tamoxifen administration caused perturbations major ...

In a study of the clinicopathologic syndrome of toxicity to phenacetin at the range of the acute, oral LD50j Boyd in 1959 (1) used adult female rats and reported the LD50±SE to be 1.65±0.35 g/kg body weight. In 1968, Boyd and Hottenroth (2) studied the toxicity of phenacetin at the range of the oral LD50 (100 days) and reported the acute oral LD50 ±SE in young male albino rats to be 4.14±0.71 g...

Objectives: Exposure to chromium, the transition element found in many compounds of earth’s crust, leads to various health hazards including cancer, dermatitis, damage of liver and kidneys, and reproductive toxicity in both male and female. Toxic effect of chronic exposure to chromium at low environmentally relevant dose is recently recognized and less studied. In the present study, we evaluate...

Aim: To evaluate the effect of aqueous extract Hypoestes rosea (AEHR) leaf on thyroid hormones in lead-acetate-induced Albino Rats.
 Study design: Experimental study.
 Place and Duration Study: Department Pharmacology, University Port Harcourt Chemical Pathology, Harcourt, between October, 2019 March, 2020.
 Methodology: A total 140 albino Wistar rats were used for study. The ani...

Quinalphos is a toxic organophosphate pesticide having a wide applicability to control pests in a number of vegetable crops like ladyfinger, brinjal, cauliflower etc. due to its good penetrative properties and long residual action in animals. The present investigation was carried out to determine its toxic effects on reproduction in the female albino rats. Technical quinalphos (2 mg/kg body wei...

Three different crude drug combinations viz; the extracts of bark, leaf and stem of A. indica; fruits of P. longum and berries of E. ribes prepared using different solvents were tested for their anti-ovulatory effect in female albino rats. The first and third combinations have shown promising results in terms of prolongation of disastrous phase of estrous cycle.