The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible, chloroquine-intermediate, and chloroquine-resistant, culture-adapted Plasmodium falciparum lineages by a proliferation test. One of the ferrocene analogs totally restored the activity of chloroquine against chl...

A naturally occurring nanoparticle, the plant virus Cowpea mosaic virus, can be decorated with ferrocene derivatives, of various linker lengths with amine and carboxylate groups, on the external surface using a range of conjugation strategies. The multiple, organometallic, redox-active ferrocene moieties on the outer surface of the virus are electrochemically independent with reduction potentia...

The oxidation of a rhodium(I) complex containing a ferrocene-based heterodifunctional phosphine N-heterocyclic carbene (NHC) ligand produces a stable, planar chiral rhodium(III) complex with an unexpected C-H activation on ferrocene. The oxidation of rhodium(I) to rhodium(III) may be accomplished by initial oxidation of ferrocene to ferrocenium and subsequent electron transfer from rhodium to f...

The direct synthesis of 1,1?,2,2?-tetralithioferrocene from 1,1?,2,2?-tetrabromoferrocene is reported. In addition, the related 1,1?,2,2?,3,3?-hexalithioferrocene also described, prepared directly 1,1?,2,2?,3,3?-hexabromoferrocene. These lithioferrocenes may be isolated as orange red (tetralithio) and (hexalithio) powders, respectively. When these are in situ reacted with chlorotrimethylsilane,...

The interaction of ferrocene-boronic acid with fructose is investigated in aqueous 0.1 m phosphate buffer at pH 7, 8 and 9. Two voltammetric methods, based on 1) a dual-plate generator-collector micro-trench electrode (steady state) and 2) a square-wave voltammetry (transient) method, are applied and compared in terms of mechanistic resolution. A combination of experimental data is employed to ...

This paper describes the synthesis and application of a novel ferrocene (Fc) label that can be efficiently attached to oligonucleotides. We demonstrate how pulse electrochemical methods can be used to measure very low concentrations of ferrocene label and, importantly, show good electroanalytical discrimination between a labelled oligonucleotide and an enzyme digested labelled oligonucleotide, ...

Ferrocene and Ruthenocene are dicyclopentadienyl complexes, where the metal (Fe and Ru) is sandwiched between two cyclopentadienyl structures. The paper describes a comparative study of the electronic and geometric structural properties of ferrocene and ruthenocene. The various physical properties (stability, geometry, symmetry etc.) of the two are reviewed to elucidate the differences between ...

Ferrocene since its inception in the year 1951, has been extensively exploited as a crucial redox probe to unravel electrochemical charge-transfer dynamics variety of platforms ranging from solution-based systems and molecular thin-films solid-state electronics spintronic devices. Having completed almost 71 years existence, ferrocene now become one most widely studied organometallic compounds. ...

Current trends in the development of on-site diagnostic tests using immunodetection principles are proceeding in two directions: toward the immunochromatography test strip and toward the immunosensor. To develop both applications for the detection of digoxin, we prepared multilabeled antibody conjugates using colloidal gold and ferrocene. Prior to applying the digoxin antibody in immunochromato...

We report the synthesis and application of a specific electroactive label, N-(2-ferrocene-ethyl)maleimide, which provides new redox properties to organic compounds and proteins possessing sulphydryl groups. Its reaction conditions with the cysteine-containing peptide, glutathione, and a terminal monooxygenase enzyme, cytochrome P450cam are presented. The labelled peptide and enzyme acquired rev...