Background Fetal growth restriction is the second leading cause of perinatal morbidity and mortality. The incidence of intrauterine growth restriction (IUGR) is estimated to be approximately 5 percent in the general obstetric population. Abnormal uterine artery suggest a maternal cause for the growth restriction where as normal uterine artery Doppler studies suggest that a fetal cause. Use of u...

Galinsky R, Jensen EC, Bennet L, Mitchell CJ, Gunn ER, Wassink G, Fraser M, Westgate JA, Gunn AJ. Sustained sympathetic nervous system support of arterial blood pressure during repeated brief umbilical cord occlusions in near-term fetal sheep. Am J Physiol Regul Integr Comp Physiol 306: R787–R795, 2014. First published March 19, 2014; doi:10.1152/ajpregu.00001.2014.—Sympathetic nervous system (...

BACKGROUND AND PURPOSE Maternal glucocorticoid treatment for threatened premature delivery dramatically improves neonatal survival and short-term morbidity; however, its effects on neurodevelopmental outcome are variable. We investigated the effect of maternal glucocorticoid exposure after acute asphyxia on injury in the preterm brain. METHODS Chronically instrumented singleton fetal sheep at...

Rhodamine B fluorescence is presented as a simple, rapid, highly sensitive, permanent method for the histologic detection of squames in maternal amniotic fluid emboli and fetal lungs in cases of intrauterine asphyxia. The method may be used on alcohol fixed smears or formalin fixed paraffin sections. The application of this procedure allows for identification of sparsely distributed fetal squam...

Background & aim: The caesarean rate is on the rise in Cameroon; nonetheless, there is a paucity of data regarding its associated risk factors and outcomes.  This study aimed to determine the associated risk factors, as well as maternal and fetal outcomes of caesarean delivery in four hospitals in Cameroon. Methods:</str...

: Hemodynamic changes accompanying the initial breaths at time of birth are especially important for a smooth transition fetal to neonatal circulation. Understanding normal transitional physiology and clinical impact adverse adaptation is delineating pathology so as guide physiologically relevant therapies. Disorders such severe perinatal asphyxia, hemodynamically significant patent ductus arte...

The degree of asphyxia is best ascertained by measuring the amount of fetal acidosis determined by umbilical arterial blood. An umbilical arterial pH of less than 7.0 is seen in about 0.3% of deliveries.1 It indicates a severity of acidosis that places the fetus at risk for permanent neurological damage because of asphyxia. However, the outcome of infants with umbilical cord pH of less than 7.0...

The fetal environment and circulatory patterns are very different from that of extrauterine life. fetus evolved to thrive grow in a relative hypoxemic adapted several mechanisms response changes oxygen concentration the blood ensure optimal delivery brain heart. However according estimates World Health Organization world 4 9 million newborns born annually state perinatal asphyxia. In economical...