نتایج جستجو برای: fimm
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The conclusions of Bavelier, Newport, Hall, Supalla, and Boutla (2006, this issue) are undermined by an inappropriate procedure for measuring articulation rate. They measured duration for reading a matrix of 200 letters (D. Bavelier, personal communication, May 17, 2006), which may involve a considerable load on visual attention, translation from print, and articulatory planning. This procedure...
Although poorly understood, androgen receptor (AR) signaling is sustained despite treatment of prostate cancer with antiandrogens and potentially underlies development of incurable castrateresistant prostate cancer. However, therapies targeting the AR signaling axis eventually fail when prostate cancer progresses to the castrate-resistant stage. Stat5a/b, a candidate therapeutic target protein ...
Purpose: To identify novel therapeutic opportunities for patients with prostate cancer, we applied high-throughput screening to systematically explore most currently marketed drugs and drug-like molecules for their efficacy against a panel of prostate cancer cells. Experimental Design: We carried out a high-throughput cell-based screening with proliferation as a primary end-point using a librar...
Featured Article: Tissue microarrays for highthroughput molecular profiling of tumor specimens. Kononen J, Bubendorf L, Kallioniemi A, Bärlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP. Nat Med. 1998;4:844 –7. Tissue specimens are essential for biomedical and clinical research. In situ detection of DNA, RNA, and protein targets in tissues provides a powerful me...
1) I am not sure if the trendlevel result for the influence of sad mood on one of the three visuospatial tests is justification enough for the conclusion: “...alertness and – to a lesser extend – sad mood led to left omissions in visuospatial neglect tests”. The manuscript has been changed accordingly (p.2, ll.10-12). Background: 2) In the literature, the term “unilateral neglect” seems to be c...
The Somatic Marker Hypothesis (SMH) proposes that physiological feedback to the brain influences cognitive appraisal and decision-making; however, the strength of evidence in support of the SMH is equivocal. In this study we examined the validity of the SMH by measuring physiological arousal in a population of healthy individuals playing the Iowa Gambling Task (IGT); a computerised card game de...
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