PURPOSE To determine cumulative incidence and predictors of new-onset seizures in mild Alzheimer's disease (AD) with a cohort followed prospectively. Limited information is available on the incidence of seizures, and no reports exist of seizure predictors in AD patients. METHODS Mild AD patients were prospectively followed at 6-month intervals to estimate incidence of unprovoked seizures, com...

of the Clinical Problem Approximately150000adultspresenteachyearwithanunprovoked first seizure in theUnited States, although less thanhalf have a readilyapparentcause.1 It is important todistinguishseizures fromevents that canmimic epilepsy, such as syncope,movement disorders, and toxic-metabolicencephalopathy,andrecongizethat transient factors that temporarily lowerseizurethreshold inanotherwi...

New diagnostic criteria define epilepsy as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. Two factors are associated with an increased risk of relapse: the presence of a cerebral lesion and epileptiform abnormalities (EA) in the electroencephalogram (EEG). In this paper we focus on the risk of relapse after a first unprovoked seizure; we revi...

The approach to a child who has experienced a first unprovoked generalized tonic-clonic seizure is challenging and at the same time controversial. How to establish the diagnosis, ways and means of investigation and whether treatment is appropriate, are different aspects of this subject. In this writing the above mentioned matters are discussed.

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Seizures are the most common pediatric neurologic disorder. Four to ten percent of children suffer at least one seizure in the first 16 years of life. The incidence is highest in children less than 3 years of age, with a decreasing frequency in older children. Epidemiologic studies reveal that approximately 150,000 children will sustain a first-time unprovoked seizure each year, and of those, 3...

Epilepsy is a tendency of brain to have recurrent unprovoked seizures. Traditionally, the diagnosis of epilepsy has been made after having two unprovoked seizures greater than 24 hours apart. According to recent revised definition by International League Against Epilepsy (ILAE), epilepsy definition includes one unprovoked (or reflex) seizure and a probability of further seizures similar to gene...