Silymarin, an extract of the seeds of Silybum marianum L. (milk thistle), is used for treatment of liver diseases. It contains several active flavonolignans; the major are silybin, which is a mixture of diastereomers A and B, and silychristin. Low bioavailability of silybin and silychristin is related to low water solubility of these compounds. In order to enhance the solubility, S. marianum dr...

Radiotherapy is the most common cancer treatment modality applying ionizing radiation. In majority of the cases, RT necessarily affects on normal tissues around the tumor. Silymarin is one of the most important chemical ingredients of the milk thistle. Silymarin composed of six flavonolignans that Silibinin, with 40-50%, is the most one. In view of the innumerable beneficial effects of silymari...

Polygonum capitatum (Polygonaceae) exists in rural areas of Southwest China and some other Asian countries. Its aerial part or whole herbal plant has been used as a Miao ethnomedicine against urinary system diseases, infections, pyelonephritis, diarrhea, so on. The progress phytochemical research on P. over the past decades is summarized. Two hundred three chemical constituents that have isolat...

silymarin is a mixture of flavonolignans from the seeds of silybum marianum (l.) gaertner,containing silybinin, isosilybinin, silydianin, silychristin and the dihydroflavonol of taxifolin. flavonolignancomponents are largely responsible for the medical benefits attributed to silymarin. the aim of this researchwas to study the variations in composition and content of flavonolignans of silymarin ...

Silymarin, a mixture of antihepatotoxic flavonolignans used in the treatment of liver diseases, and lactulose, a nonabsorbable synthetic disaccharide, were investigated to analyze their probable synergic and healing effects in a hepatic cirrhotic rat model. Liver damage was induced by the administration and subsequent withdrawal of thioacetamide. The significant decrease in liver enzymes and ma...

Women at high risk of developing breast cancer are prescribed selective estrogen response modulators, including raloxifene, as chemoprevention. Patients often seek complementary and alternative treatment modalities, including herbal products, to supplement prescribed medications. Milk thistle preparations, including silibinin and silymarin, are top-selling herbal products that may be consumed b...