Subarachnoid hemorrhage (SAH) resulting from a ruptured intracranial aneurysm can induce cerebral vasospasm with subsequent reduction in cerebral blood flow (CBF). The present study examines the pathological alterations in the wall of human cerebral arteries at autopsy, especially with regard to intimal pathology, following aneurysmal SAH. Arterial segments from the circle of Willis were fi...

Arterial disease, especially Coronary Artery Disease (CAD) is one of the leading causes of premature morbidity and mortality. During the flow, blood not only interacts with vessel wall mechanically but also chemically which modulates the plaque formation in blood vessel thus leading to coronary artery diseases. Here we propose to simulate a MEMS based flexible flow sensor based on anemometer pr...

Arachidonic acid, the precursor of all bisenoic prostaglandins, is the most common fatty acid present in cellular phospholipids and can be obtained directly from the diet or by desaturation and chain elongation from dietary linoleic acid (C18:2 w-6). Arachidonic acid is liberated from membrane phospholipids by the action of phospholipases, activated by changes in their chemical environment. Sim...

1. Infusion of sufficient renin to raise the blood pressure of normal rats to hypertensive levels resulted in increased renin in the arterial wall. 2. Arterial wall renin and renal venous renin were normal in younger spontaneously hypertensive rats, but in older spontaneously hypertensive rats arterial wall renin was significantly increased and renal venous renin was significantly decreased. 3....

White blood and black blood magnetic resonance imaging methods are often used for lumenography and visualization of the arterial wall, respectively. However, the use of white blood imaging invariably obscures arterial wall boundaries, and thus, impedes precise measurement of arterial wall area. Conversely, black blood imaging imposes strict limits on sequence timing to suppress the arterial lum...

OBJECTIVE Liver-derived apolipoprotein E (apoE) decreases atherosclerosis without altering the circulating concentrations of plasma lipoproteins. We evaluated the effects of apoE and lipoprotein lipase (LpL) on the interactions of triglyceride-rich particles (TGRPs) in the arterial wall. METHODS AND RESULTS Quantitative fluorescence microscopy was used to study the interactions of TGRPs (25- ...

The assumption of incompressibility has often been applied to the analysis of arterial-wall elasticity; however, the supporting evidence has been incomplete. The present study was designed to explore this problem in greater depth by accurately measuring the changes in tissue volume associated with large, induced strains on 11 thoracic aorta segments excised from dogs. The radial, circumferentia...

Plasma plasminogen activator inhibitor type 1 (PAI-1) increases in diabetes, and this might contribute to decreased fibrinolysis and accelerated atherosclerosis. Increased PAI-1 levels in the vessel wall could decrease local fibrinolysis and elevate thrombus formation and the unfavorable evolution of atherosclerotic plaques. High glucose increases PAI-1 synthesis in arterial wall cells in cultu...

Intimal hyperplasia, common at the deployment site of an intra-arterial stent, may be caused by artery wall hypoxia. The purpose of this study was to determine the effect of an intra-arterial stent on artery wall oxygen concentrations. Transarterial wall oxygen gradients were measured by microelectrode at stent deployment sites in New Zealand White rabbits. Thinned artery walls and decreased ox...

The objective of this work is to prevent damage the arterial wall, using a theoretical model hyperelastic, anisotropic, and dynamic behavior human arterial. This mainly focused on properties hydrostatic stress evolution stenosis. stenosis in order understand effect size plaque deposit, loss elasticity increase density blood mechanical wall. great contribution shows us that increasing also incre...