According to reports, Candida albicans is believed to be the leading cause of fungal urinary tract infections, otherwise known as Candiduria. Prevention of candiduria using natural products is desirable and should be investigated. The current study reports the antimicrobial effect of H. sabdariffa (Roselle) extract, a common herbal drink, in combination with voriconazole or fluconazole against ...

Candida albicans is an opportunistic fungi that is able to thrive in many host niches, including the skin, mucosal, surfaces, the blood stream and internal organs. Agglutinin-like sequence (ALS) genes which could play a role in forming biofilms, adherence to host surfaces as a virulence factor and antifungal drug resistant. The purpose of the present study was to evaluate the presence ALS1 and ...

background and objectives: vulvovaginal candidiasis is a common fungal infection among women during reproductive ages. although, candida albicans is accounted as the main etiologic agent of vaginitis, non- albicans species have arisen during last years. resistant to antifungal drugs especially, fluconazole has been more reported by researchers from around the world. the aims of this study were ...

The current study aimed to identify the differences presented in the proteome of fluconazole-susceptible isolates of Candida glabrata compared to those with fluconazole-resistant ones. Two-dimensional differential gel electrophoresis was applied to identify proteins that were differentially expressed in fluconazole-susceptible and fluconazole-resistant isolates of C. glabrata. Eight proteins in...

Among the 162 Candida tropicalis isolates collected in the Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 1999, 23 (14.2 %) had fluconazole MICs > or = 64 mg l(-1), and thus fulfilled the definition of resistance. Random amplified polymorphic DNA assay showed that all 23 fluconazole-resistance C. tropicalis isolates collected from different hospitals around Taiwan were closely rel...

introduction candidiasis as an opportunistic infection is created by some species of candida. here the role of candida albicans is more noticeable than other species. candida can cause an extended spectrum of symptoms. due to the increasing consumption of immunosuppressants including corticosteroids and diseases like diabetes, candidiasis has drawn more attention than before. methods considerin...

Abstract We investigated the clinical outcomes and molecular mechanisms of fluconazole-resistant (FR) Candida glabrata bloodstream infections. Among 1,158 isolates collected during multicenter studies in South Korea 2008–2018, 5.7% were FR. For 64 patients with FR infection isolates, 30-day mortality rate was 60.9% 90-day 78.2%; these rates significantly higher than fluconazole-susceptible dose...

Ten clinical isolates of Candida albicans, five strains belonging to each of fluconazole resistant and susceptible groups isolated from diabetic patients, were studied for the membrane fluidity and lipid composition. Compared to fluconazole susceptible strains, fluconazole resistant ones exhibited enhanced membrane fluidity as measured by fluorescence polarization technique. The increased membr...

The sterol 14-demethylase P450 (CYP51) of a fluconazole-resistant isolate of Candida albicans, DUMC136, showed reduced susceptibility to this azole but with little change in its catalytic activity. Twelve nucleotide substitutions, resulting in four amino acid changes, were identified in the DUMC136 CYP51 gene in comparison with a reported CYP51 sequence from a wild-type, fluconazole-susceptible...

The ability of a fluconazole-containing agar screen assay to accurately detect isolates of Candida glabrata resistant to the azole antifungal agent fluconazole was evaluated on a collection of 100 clinical isolates of this organism. Results were correlated with the MIC of fluconazole for these isolates and compared with the results of a previously published disk diffusion-based fluconazole resi...