This study compared the immunosuppressive effects of dexamethasone (DEX), flunixin meglumine (FLU) and meloxicam (MEL) on the peripheral blood mononuclear cells (PBMCs) of seven healthy Holstein calves in vitro. DEX significantly inhibited lymphocyte proliferation and expression of interferon (IFN)-γ, interleukin (IL)-2 and IL-4 messenger RNA (mRNA) in comparison with FLU and MEL. FLU and MEL d...

Hot-iron branding is painful for cattle, but little is known about the duration of or effective methods to control this pain. This work quantified pain sensitivity and healing in branded and unbranded animals. In addition, the effects of a single injection of nonsteroidal anti-inflammatory drug (NSAID) were also considered; this has been suggested as practical method of mitigating pain in the h...

Case Description- A five-year-old Arabian stallion weighing approximately 300 kg with large infected chronic torn wound on the neck and pectoral region 5 days after IM injection of flunixin meglumine with history of anorexia, depression and lack of response to antibacterial treatment referred to the Veterinary Teaching Hospital of Lorestan University. Clinical Fin...

The combination of the powerful antimicrobial agent florfenicol and the nonsteroidal anti-inflammatory flunixin meglumine is used for the treatment of bovine respiratory disease (BRD) and control of BRD-associated pyrexia, in beef and nonlactating dairy cattle. This study describes the development and validation of an HPLC-UV method for the simultaneous determination of florfenicol and flunixin...

The lack of an effective treatment for endotoxemia causes high mortality rates in affected animals. Forty clinically healthy 1-year old Iranian fat-tailed ewes were assigned randomly into 8 experimental equal (n = 5) groups, comprising Insln 1.5, Insln 3, Insln 6, Insln 9, Insln 20, Dexa, Flnx and Control. Lipopolysaccharide from E. coli serotype O55:B5 was used to induce endot...

According to a survey, non-steroidal anti-inflammatory agents were the most popular analgesic used in South Africa for management of peri-operative pain, acute post-operative pain and chronic pain. The most popular non-steroidal anti-inflammatory agents are flunixin meglumine and phenylbutazone. The most popular opioid type drug is buprenorphine, followed by morphine. In the peri-operative sett...

Evidence of pain perception in fish is well established, but analgesic use aquaculture limited. The objective was to investigate the comparative pharmacokinetics flunixin administered intramuscularly (IM) and meloxicam IM or orally (PO) tilapia. Two hundred seventy were assigned 1 3 treatment groups: meglumine (2.2 mg/kg); (1 PO mg/kg). Blood tissue samples collected from 6 per at 14 time point...