metric (mapping evapotranspiration at high resolution with internalized calibration) is known as an appropriate surface energy balance model for the estimation of the spatial distribution of evapotranspiration (et) in semi-arid regions. based on lysimeter measurements, metric has shown et estimates of 10% on a sub-field scale on a daily basis. there is a need to identify how the model is sensit...

One of the long-expected goals of genome-scale metabolic modeling is to evaluate the influence of the perturbed enzymes to the flux distribution. Both ordinary differential equation (ODE) models and the constraint-based models, like Flux balance analysis (FBA), lack of the room of performing metabolic control analysis (MCA) for large-scale networks. In this study, we developed a Hyper-Cube Shri...

Flux balance analysis (FBA) is one of the most often applied methods on genome-scale metabolic networks. Although FBA uniquely determines the optimal yield, the pathway that achieves this is usually not unique. The analysis of the optimal-yield flux space has been an open challenge. Flux variability analysis is only capturing some properties of the flux space, while elementary mode analysis is ...

Background Biological processes such as metabolism, signaling, and macromolecular synthesis can be modeled as large networks of biochemical reactions. Large and comprehensive networks, like Metabolic-Expression networks that explicitly accounts for the demands of macromolecular synthesis at single nucleotide resolution, are inherently multiscale because reaction rates can vary over many orders ...