The precise temporal-spatial regulation of the p21-activated serine-threonine kinase PAK at the plasma membrane is required for proper cytoskeletal reorganization and cell motility. However, the mechanism by which PAK localizes to focal adhesions has not yet been elucidated. Indirect binding of PAK to the focal adhesion protein paxillin via the Arf-GAP protein paxillin kinase linker (PKL) and P...

S U M M A R Y We present a statistical analysis of focal mechanism orientations for nine California fault zones with the goal of quantifying variations of fault zone heterogeneity at seismogenic depths. The focal mechanism data are generated from first motion polarities for earthquakes in the time period 1983–2004, magnitude range 0–5, and depth range 0–15 km. Only mechanisms with good quality ...

The carboxy-terminal 150 residues of the focal adhesion kinase (FAK) comprise the focal adhesion-targeting sequence, which is responsible for its subcellular localization. The mechanism of focal adhesion targeting has not been fully elucidated. We describe a mutational analysis of the focal adhesion-targeting sequence of FAK to further examine the mechanism of focal adhesion targeting and explo...

BACKGROUND In patients late after surgical repair of congenital heart disease (CHD), areas with abnormal electrophysiologic properties may serve as slow conducting pathways within a macroreentrant circuit or may be the source of focal atrial tachycardia. OBJECTIVES The purpose of this study was to evaluate the role of abnormal areas during focal atrial tachycardia prior to ablation. METHODS...