Discrete high-frequency oscillations (HFOs) in the range of 100-500 Hz have previously been recorded in human epileptic brains using depth microelectrodes. We describe for the first time similar oscillations in a cohort of unselected focal epileptic patients implanted with EEG macroelectrodes. Spectral analysis and visual inspection techniques were used to study seizures from 10 consecutive pat...

normal 0 false false false en-us x-none ar-sa epilepsy is more common in patients with multiple sclerosis (ms) than in the general population, occurring in 2%–3% of patients. convulsions may be either tonic–clonic in nature or partial complex. in these individuals, seizures most likely result from lesions present in the cerebral cortex and subcortical white matter. a jacksonian seizure is a typ...

Interictal and particularly ictal surface and invasive recordings allow, in most of cases, the precise localization of the cortical area responsible of ictal discharges. During surface Video-EEG the localization could be a little complicated, considering the presence of artefacts, but the occurrence of a low voltage fast activity or a fl attening, permits, coupling with the onset of clinical sy...

Reflex seizures are a rare form of epilepsy, the pathogenesis of which is unclear. They have been reported in the setting of non-ketotic hyperglycemia (NKH) and are considered to be neuroendocrine in origin. We report a diabetic patient with movement-induced seizures whose presentation suggests that brain ischemia may be the precipitating event in focal seizures seen in the setting of NKH. We r...

The effectiveness of long term EEG monitoring in the localization of the epileptic focus was studied in 37 patients with temporal lobe epilepsy comprising 190 recorded seizures, in 19 frontal lobe epileptic patients with 172 recorded seizures and in 12 additional patients which were classified as fronto-temporal. In the temporal lobe group, 49/190 seizures began focally (26%) and 20/190 seizure...

Epileptic seizures of focal origin often occur unpredictably as do interictal spikes. It is often assumed that spikes increase prior to seizures of focal origin and that antiepileptic medication affects spikes and seizures in a parallel fashion. We review evidence that this assumption is invalid and that there is a clear dissociation between spikes and seizures: increases in spiking before seiz...

background: gap junctions (gjs) provide direct intercellular communications that are formed by hexameric protein subunits, called connexin (cx). the role of cxs in epileptogenesis has not received sufficient attention. hippocampus with critical function in epileptogenesis has a wide network of gjs. we examined the protein expression levels of hippocampal cx36 (the prominent cx present between g...

INTRODUCTION There is limited information on ictal unilateral eye blinking (UEB) as a lateralizing sign in focal seizures. We identified two patients with UEB and propose a novel mechanism of UEB based on a review of the literature. MATERIALS AND METHODS We report on two patients with intractable focal epilepsy showing UEB among 269 consecutive patients undergoing noninvasive video-EEG monito...

Negative phenomena can occur with seizures, but inhibitory motor seizures are rare and may lead to misdiagno� sis. Two adults with focal inhibitory motor seizure (ictal paralysis) have been evaluated, and taken together with the clinical history, the results from these investigations suggest focal inhibitory seizures as the underlying etiology. The mechanisms of negative motor phenomena during ...

Limbic motor seizures in animals, analogous to complex partial seizures in humans, result in a consistent activation of the mediodorsal thalamus (MD) and, with prolonged seizures, damage to MD. This study examined the functional role of MD in focally evoked limbic motor seizures in the rat. GABA- and glutamate (Glu)-mediated synaptic transmissions in MD were evaluated for an influence on seizur...