Formaldehyde fixatives have traditionally been used to preserve tissues as they impart excellent morphological preservation. Formaldehyde fixes tissue by cross linking, a process which can reduce the antigenicity of tissue and weakens the intensity of immunohistochemical stains. Preliminary studies have shown that Histochoice tissue fixative offers equal or greater staining intensity than neutr...

During the early phases of tissue sectioning for electron microscopy, virtually all of the standard cytological fixatives were tried. Of these, osmium tetroxide appeared to give the best preservation, and this was further improved by buffering the fixative solution at a slightly alkaline pH (Palade (1)). A variant developed by Dalton (2) contains Os04 in a chromate-dichromate system. Formalin h...

Millions of scientific specimens are housed in museum collections, a large part which fluid preserved. The use formaldehyde as fixative and subsequent storage ethanol is especially common ichthyology herpetology. This type preservation damages DNA reduces the chance successful retrieval genetic data. We applied ancient extraction single stranded library construction protocols to variety vertebr...

The field of surgical pathology is diagnostic in nature and since its inception, has always supported the treatment of cancer. The manner by which tissues are processed may vary between institutions, but the vast majority utilize formaldehyde as the fixative of choice. This fixative allows for excellent architectural tissue preservation thereby enabling optimal microscopic examination, the foun...

Formalin-fixed tissue has been a mainstay of clinical pathology laboratories, but formalin alters many biomolecules, including nucleic acids and proteins. Meanwhile, frozen tissues contain better-preserved biomolecules, but tissue morphology is affected, limiting their diagnostic utility. Molecular fixatives promise to bridge this gap by simultaneously preserving morphology and biomolecules, en...