BACKGROUND In order to enhance the absorption of insulin following subcutaneous injection, excipients were selected to hasten the dissociation rate of insulin hexamers and reduce their tendency to reassociate postinjection. A novel formulation of recombinant human insulin containing citrate and disodium ethylenediaminetetraacetic acid (EDTA) has been tested in clinic and has a very rapid onset ...

Background: Starch of sweet potatoes is one the ingredients that has many benefits, including in pharmaceutical field, especially as a excipient formulations. But it poor flow properties. Objective: The objective study to isolate, characterise, modify and formulate starch Purple (I. batatas L.Poir) into tablet dosage forms. Method: purple potato obtained from isolation, then modified improve it...

In the present study, novel co-processed superdisintegrants were developed by solvent evaporation method using crospovidone and sodium starch glycolate in different ratios (1:1, 1:2 & 1:3) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. The...

The primary objective of this study is to evaluate the effect of drug loading and the effect of excipients on the release pattern of Dexamethasone Sodium Phosphate from in situ PLGA implants formed in vitro in gelatin gel. This system is prepared by dissolving a biodegradable polymer (DL-PLGA 70K) in dimethyl sulfoxide (DMSO). Then the drug with excipients or without excipients was added to it....

Drug products not only contain “actives” that confer the intended therapeutic benefits such as pain relief or act on particular part of the body, but contain other materials that are also “functional” with respect to the drug product. These are known as excipients and specific functionality which they confer to a particular product is independent upon the process used to add the excipient to th...

BACKGROUND The compatibility study of active substances with excipients finds an important role in the domain of pharmaceutical research, being known the fact that final formulation is the one administered to the patient. In order to evaluate the compatibility between active substance and excipients, different analytical techniques can be used, based on their accuracy, reproducibility and fastn...

orally disintegrating tablets (odts) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. the aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...

Objective: The research aims to formulate and evaluate Solid Dispersion tablets of Silymarin. Methods: dispersions Silymarin were prepared with various concentrations carriers by using solvent evaporation method. solid compressed into 8 mm punch rotary tablet punching machine, the hardness 3.5kg /cm2.The formulated evaluated for quality control parameters. Results: was mixed proportions excipie...

The objective of this study was to determine the effects of formulation excipients and physical characteristics of inhalation particles on their in vitro aerosolization performance, and thereby to maximize their respirable fraction. Dry powders were produced by spray-drying using excipients that are FDA-approved for inhalation as lactose, materials that are endogenous to the lungs as albumin an...