The pointwise linear regression (PROGRESSOR) technique for visual field analysis and display, described in this issue (p 000) by Viswanathan et al, deserves consideration beyond the comparison of its sensitivity with the STATPAC 2 program. Is it a fashionable solution which has yet to find its problem; yet another technical complexity oVered to a medical market often driven by the interest of s...

Even on a plain wall chart, the intricacies of a cell’s biochemical pathways can boggle the mind. Hundreds of interweaving routes create and consume thousands of intermediate compounds, which are regulated by a dizzying number of enzymes at every step—a drop in nutrient A turns on pathway B to make intermediate C that is converted to regulator D that stimulates gene E that creates enzyme F to d...

One of the key goals of modern cell and developmental biology is to expose the underlying principles that drive cell differentiation and to elucidate how organisms construct functional multicellular structures. Thanks to advances in sequencing, high throughput screens and sophisticated imaging technologies, these fields are now awash with quantitative descriptions of gene transcription, cell si...

In this issue of Cell, Langen et al. use time-lapse multiphoton microscopy to show how Drosophila photoreceptor growth cones find their targets. Based on the observed dynamics, they develop a simple developmental algorithm recapitulating the highly complex connectivity pattern of these neurons, suggesting a basic framework for establishing wiring specificity.