Adenovirus is a common viral infection with variable clinical presentations, including respiratory tract infection, conjunctivitis, and gastroenteritis. In immunocompromised patients, it can present more severely with liver failure, renal failure, encephalitis, pancreatitis, myocarditis, and even disseminated disease. We report a case of acute liver failure caused by adenovirus in a previously ...

Activation of the immune coagulation system has been implicated in the pathogenesis of fulminant liver failure caused by murine hepatitis virus strain 3 (MHV-3). The recent discovery of the fgl2 gene, which encodes for MHV-3-induced prothrombinase (fgl2 prothrombinase), allows for fundamental studies to determine the molecular basis for fulminant liver failure. Transcription of the fgl2 gene an...

A favourable outcome of fulminant liver failure by replacement treatment with antithrombin III, prothrombin concentrate, fresh frozen plasma, and plasminogen is reported. Haemostatic balance was maintained and no severe bleeding complications occurred during the 15 days of disturbed liver function.

Autoimmune hepatitis initially presenting as fulminant hepatic failure is rare in clinical practice. Although corticosteroid is considered as a good therapeutic agent in treating autoimmune hepatitis in the literature, the effect of corticosteroid in treating fulminant autoimmune hepatitis is still controversial. Because corticosteroid therapy for fulminant autoimmune hepatitis can sometimes ov...

Fulminant and subacute hepatitis are conditions characterized by rapid liver failure, which can lead to death in 80 to more than 95% of the cases with medical supportive care only. The etiology can be viral, drug-, or other chemical-induced, metabolic, etc. Orthotopic liver transplantation emerged during the 1980s as a powerful means for dealing with these diseases. The existence of this therap...

OBJECTIVE To see whether intravenous acetylcysteine would improve outcome in patients with fulminant hepatic failure after paracetamol overdose. DESIGN A prospective randomised controlled study. SETTING The Institute of Liver Studies, King's College Hospital, London. PATIENTS 50 consecutive patients (21 male) aged 16-60 with fulminant hepatic failure after paracetamol overdose who had not...

Mortality rates for fulminant hepatic failure range between 50% and 90%. Several independent factors influence survival: age, etiology, depth and duration of the encephalopathy, and prevention of complications. The main causes of fulminant hepatic failure are hepatotropic viruses, adverse drug effects, and toxins (Table 1). All major hepatotropic viruses can induce fulminant hepatic failure. We...

Dengue virus infection continues to be major public health problem in large part of world. The epidemiology of dengue viral infection is becoming increasingly complex and has substantially changed over almost past six decades not only in terms of prevalent strains and geographical locations but also in terms of disease severity and atypical presentations. Though liver is the most common organ a...

There have been very few reports dealing with liver failure related to hepatitis A in children. Moreover, the criteria usually used for selecting patients with fulminant hepatitis A for liver transplantation have not been evaluated in children. Therefore, the current study was conducted retrospectively in a single French urban pediatric liver transplantation center to serve as a reminder of the...