نتایج جستجو برای: functional pituitary adenomas
تعداد نتایج: 631995 فیلتر نتایج به سال:
Pituitary adenomas are common benign tumors that may or may not produce hormones that are rarely malignant. Those that do not generate hormones are considered non-functioning or non-secretory. Non-secretory pituitary adenomas are defined as tumors of the pituitary gland that lack the characteristic of hormone hypersecretion and account for 18 to31% of all surgically treated pituitary adenomas [...
As for any solid tumour, pituitary adenoma expansion is dependent on neovascularization through angiogenesis. In this process, vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, VEGFR-2 and neuropilin-1 (NRP-1) may play an outstanding role. The intention of this work was to study the expression/localization and possible function of VEGF receptors in pituitary adenomas. VEGF re...
To improve visual disturbance, optic nerve decompression can be performed via transcranial or tran-sphenoidal approaches. Although the surgical exposure in transcranial approach is favourable, yet the optic nerve's presence in the field may make it vulnerable to damage. Of fighty patients with different types of pituitary adenomas, 35 cases with medium-sized (1-3 cm) tumors have been studied in...
BACKGROUND We aim to study surgical technique and analyze the related factors affecting tumor total removal and postoperative endocrinological remission for endoscopic endonasal pituitary adenomas surgery. METHODS We retrospectively analyzed 178 endoscopic endonasal pituitary adenomas surgery from March 2011 to May 2014. Endonasal approach included the routine transnasal-sphenoidal approach, ...
Clinically-relevant pituitary adenomas occur with a prevalence of approximately 1 per 1000 population in Belgium. Pituitary adenomas that occur in families are likely to have an important genetic pathophysiological basis. Currently about 5% of all pituitary adenoma cases have a family history of pituitary adenomas, classically due to multiple endocrine neoplasia type 1 (MEN1) and Carney complex...
A surgically removed pituitary adenomas, approximately 30-35% appear to be silent, unassociated with clinical or biochemical evidence of any anterior pituitary hormone excess (1, 2). However, with routine immunocytochemical staining of the pituitary tumor tissue, immunoreactive hormone material can be demonstrated in a substantial number of these seemingly nonfunctioning tumors (2). Clinically ...
UNLABELLED Although pituitary adenomas are regarded as benign tumors, some of them behave aggressively with malignant behavior of invasion and metastasis. Prediction of such biologic behavior in a tumor is important for therapeutic planning. The purpose of this study was to assess the usefulness of 201Tl chloride SPECT (201Tl SPECT) for evaluation of biologic behavior in pituitary adenomas. M...
Pituitary adenomas are one of the most common intracranial tumors. Despite their benign nature, dysregulation of hormone secretion causes systemic metabolic deterioration, resulting in high mortality and an impaired quality of life. Tumorigenic pathogenesis of pituitary adenomas is mainly investigated by performing genetic analyses of somatic mutations in the tumor or germline mutations in pati...
Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin system has been linked to development of certain endocrine-related cancers. Systematic analysis of the presence and functional implications of some components of the ghrelin sy...
Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively. Isolated familial somatotropinoma (IFS) is also a well-described clinical syndrome related only to patients with acrogigantism. Pituitary adenomas of all types--not limited to IFS--can occur in a familia...
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