Drug loaded dissolving microneedles (DMNs) fabricated with water soluble polymers have received increasing attentions as a safe and efficient transdermal drug delivery system. Usually, to reach a high drug delivery efficiency, an ideal drug distribution is gathering more drugs in the tip or the top part of DMNs. In this work, we introduce an easy and new method to introduce a bubble with contro...

In this paper, we consider series-parallel and parallel-series systems with independent subsystems consisting of dependent homogeneous components whose joint lifetimes are modeled by an Archimedean copula. Then, by considering two such systems with different numbers of components within each subsystem, we establish hazard rate and reversed hazard rate orderings between the two system lifetimes,...

The present study attempts to analyze Iraq war against Iran based on Parsons' subsystems. The main question aims at finding the social positive/negative functions of the war. According to the studies, the first effect of the war was damaging behavioral organism subsystem so that it couldn't realize its functions. Subsequently, the chaos spread to the personality subsystem. Except for the qualit...

We report the infrared spectra at 0.5 cm 1 resolution of three dimethylnaphthalenes (DMNs), namely 1,5-DMN, 1,6-DMN and 2,6-DMN in the gas phase at an elevated temperature recorded with the help of a variable path-length cell. DFT calculations have been carried out at B3LYP levels of theory with 6-31G* as basis set to determine the harmonic frequencies and intensities of the DMNs to assign the ...

Dissolving microneedles (DMNs) are polymeric, microscopic needles that deliver encapsulated drugs in a minimally invasive manner. Currently, DMN arrays are superimposed onto patches that facilitate their insertion into skin. However, due to wide variations in skin elasticity and the amount of hair on the skin, the arrays fabricated on the patch are often not completely inserted and large amount...