In fluorescence mode confocal microscopes, only 0.02% of emitted signal can be detected in best case. So, we proposed reflecting optical system to increase signal intensity detected in photon detector. In this paper, we evaluate the proposed reflecting optical system using optical transfer function. To evaluate the proposed system, we used the modeling method based on wave optics. We first calc...

Here, we report on the present state of development of a liquid xenon detector composed by multiwire ionisation chambers, which has been developed for positron emission tomography (PET). It uses the fast scintillation signal for coincidence and subsequent trigger of the event processing. The charge signals induced on the wires are used for position determination along the radial and transaxial ...

In a previous study, we found that Primo vessels generate different action potentials in smooth muscles, but this study compared the pulse shape to distinguish the two tissues. Thus, a more sophisticated extracellular experiment was performed in this study using an acetylcholine injection; we then observed changes in the amplitude, FWHM (full width at half maximum), and period to explore Primo ...

Introduction: Automatic arterial input function (AIF) selection has an essential role in quantification of cerebral perfusion parameters. The purpose of this study is to develop an optimal automatic method for AIF determination in dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) of glioma brain tumors by using a new preprocessing method.Material and Methods: For this study, ...

Silicon Photomultipliers (SiPM) are interesting light sensors for Positron Emission Tomography (PET). The detector signal of analog SiPMs is the total charge of all fired cells. Energy and time information have to be determined with dedicated readout electronics. Philips Digital Photon Counting has developed a SiPM with added electronics on cell level delivering a digital value of the time stam...

In our previous work, using luminosity and the Hβ FWHM as surrogates for black hole mass (MBH), we compared the black hole masses of narrow-line Seyfert 1 galaxies (NLS1s) and broad-line Seyfert 1 galaxies (BLS1s) in a sample of soft X-ray-selected active galactic nuclei. We found that the distributions of black hole masses in the two populations are statistically different. Recent work shows t...

When optimizing the timing performance of a time-of-flight positron emission tomography (TOF-PET) detector based on a monolithic scintillation crystal coupled to a photosensor array, time walk as a function of annihilation photon interaction location inside the crystal needs to be considered. In order to determine the 3D spatial coordinates of the annihilation photon interaction location, a max...

Magnetic Particle Imaging (MPI) is a quantitative mass-sensitive, tracer-based imaging technique, with potential applications in various cellular imaging applications. The spatial resolution of MPI, in the first approximation, improves by decreasing the full width at half maximum (FWHM) of the field-derivative of the magnetization, dm/dH of the nanoparticle (NP) tracers. The FWHM of dm/dH depen...

We demonstrate the use of an aperiodic quasi-phase-matching (QPM) grating to generate second-harmonic pulses that are stretched or compressed relative to input pulses at the fundamental frequency. We frequency doubled an externally chirped erbium-doped fiber laser generating 17-ps (FWHM) pulses at 1560nm to produce near-transform-limited 110-fs (FWHM) pulses at 780nm by use of a 5-cm-long lithi...

We report efficient frequency doubling of passively mode-locked femtosecond erbium-fiber lasers. Quasi-phase-matched second-harmonic generation in periodically poled lithium niobate is used to generate 8.1 mW of 190-fs (FWHM), 90-pJ pulses at 777 nm with a conversion efficiency greater than can be obtained with existing birefringently phase-matched nonlinear materials. A dispersion-compensation...