Third-generation (G3) poly(amidoamine) (PAMAM) dendrimers are simulated approaching 1,2-dimyristoyl- sn-glycero-3-phosphocholine (DMPC) bilayers with fully atomistic molecular dynamics, which enables the calculation of a free energy profile along the approach coordinate. Three different dendrimer terminations are examined: protonated primary amine, uncharged acetamide, and deprotonated carboxyl...

INTRODUCTION Rotavirus (RV) infection is the most common cause of gastroenteritis in children. This paper identifies the most common genotypes of rotaviruses isolated from children hospitalized with gastroenteritis and attempts to determine any relationship between infection with a certain rotavirus genotype. MATERIAL AND METHODS The investigated group consisted of 68 consecutive children wit...

A third-generation polyamidoamine dendrimer (PAMAM G3) was used as a macromolecular carrier for pyridoxal and biotin. The binary covalent bioconjugate of G3, with nine molecules of biotin per one molecule of G3 (G3(9B)), and the ternary covalent bioconjugate of G3, with nine biotin and ten pyridoxal molecules (G3(9B10P)), were synthesized. The biotin and pyridoxal residues of the bioconjugate w...

Let R and B be two disjoint sets of red points and blue points, respectively, in the plane such that no three points of R ∪ B are co-linear. Suppose ag ≤ |R| ≤ (a + 1)g, bg ≤ |B| ≤ (b + 1)g. Then without loss of generality, we can express |R| = a(g1 + g2) + (a + 1)g3, |B| = bg1 + (b + 1)(g2 + g3), where g = g1 + g2 + g3, g1 ≥ 0, g2 ≥ 0, g3 ≥ 0 and g1+g2+g3 ≥ 1. We show that the plane can be sub...

In [2], Brousek characterizes all triples of graphs, G1, G2, G3, with Gi = K1,3 for some i = 1, 2, or 3, such that all G1G2G3-free graphs contain a hamiltonian cycle. In [6], Faudree, Gould, Jacobson and Lesniak consider the problem of finding triples of graphs G1, G2, G3, none of which is a K1,s, s ≥ 3 such that G1, G2, G3-free graphs of sufficiently large order contain a hamiltonian cycle. In...

Peptides containing the asparagines-glycine-arginine (NGR) motif have been identified as specific ligands binding to CD13/aminopeptidase N (APN) receptor, a tumor neovascular biomarker. In this study, we synthesized a novel NGR-containing peptide (NOTA-G3-NGR), and labeled NOTA-G3-NGR with (68)Ga (t1/2 = 67.7 min). The resulting (68)Ga-NOTA-G3-NGR peptide was subject to in vitro and in vivo cha...

The concomitant influence of grandparental (Generation 1; G1) and parental (G2) substance use disorder (SUD) on grandchild (G3) emotional disorder (EmD) across three generations is unclear. The present study addressed this in a sample of 284 families participating in the Oregon Adolescent Depression Project. Structured clinical interviews were used to collect psychiatric history data on a commu...