background: hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. the present study was designed to determine the role of gamma amino butyric acid b (gabab) receptor and l-arginine (l-arg) in gaba-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. methods: diabetes was induced by a single i.p. injection of strepto...

In our present work, some novel substituted 4-phenyl-5-vinylpyrrolidin-2-one derivatives were designed, synthesized, and evaluated for their ?-aminobutyric acid-aminotransferase (GABA-AT) inhibition in-vivo anticonvulsant activity. Among all the synthesized derivatives, compound 7f was observed as most potent competitive inhibitor of GABA-AT (IC50 = 46.29 ± 3.19 µM, Ki 0.106 0.004 ?M). The acti...

background preliminary studies revealed that 4-aminobutyric acid (gaba) is a key and major inhibitory neurotransmitter in the brain. evidence from many animal studies and even some clinical studies indicate that gaba is responsible for regulating behavior and also plays an important role in brain functions. previous studies presented glutamic acid decarboxylase as a catalyst for the conversion ...

Lactiplantibacillus plantarum has been widely studied due to its beneficial effects on health such as protect against pathogens, enhance the immune system, or produce metabolites like γ-aminobutyric acid (GABA). The objective of this study was evaluation GABA-producer L. K16 isolated from kimchi. safety and probiotic characterisation strain performed by analysing carbohydrates fermentation, enz...

Behavioral flexibility and goal-directed behavior heavily depend on fronto-striatal networks. Within these circuits, gamma-aminobutyric acid (GABA) glutamate play an important role in (motor) response inhibition, but it has remained largely unclear whether they are also relevant for cognitive inhibition. We hence investigated the functional of transmitters inhibition during flexibility. Healthy...

Chile es uno de los países Latinoamérica que exhibe un mayor envejecimiento poblacional, por lo necesario visualizar distintas herramientas direccionen estilos vida saludables en esta etapa la trayectoria vital. Las Guías Alimentarias Basadas Alimentos (GABA) entregan recomendaciones permiten mejorar calidad personas mayores. Por anterior, el objetivo del estudio fue determinar nivel cumplim...

?-Aminobutyric acid (GABA) is a non-protein amino that accumulates in many plant species response to environmental stress. A number of reverse-genetic experiments and omics analyses have revealed positive relationships between GABA levels tolerance stresses. Furthermore, the application exogenous has been demonstrated effectively reduce ROS levels, enhance membrane stability modulate phytohormo...

objective(s):there is much evidence indicating that depression is influenced by the levels of neurotransmitters such as dopamine, gaba and adrenaline. the current study we designed to investigate the effect of exposure of pregnant rats to different colors on neurotransmitters level, as indicators of mood disorders in off springs. materials and methods:five groups of pregnant female wistar rats ...

The physiological and biochemical role of the ?-aminobutyric acid (GABA) shunt pathway in green pea seedlings (Pisum sativum L.) was studied response to soil water holding capacity levels: 80%, 60%, 40%, 20%, 10% grown under continuous light at 25 °C for 7 days 14 days, separately. Characterization seeds germination pattern, growth (plant height, fresh dry weight, chlorophyll contents), GABA me...

Fresh peaches are highly perishable and they deteriorate quickly during low temperature storage which results in losses in nutritional quality. To prevent these adverse effects, peach fruits were treated by dipping with γ-aminobutyric acid (GABA; 2, 4 and 6 mM) immediately after harvest and then stored at 1 °C for 7, 14, 21, and 28 days. Peach fruits treated with GABA exhibited higher flesh fir...