γ-Glutamyl transpeptidase (5-L-glutamyl-peptide: amino acid 5-glutamyl transferase; EC 2.3.2.2; abbreviated GGT), is a plasma membrane-associated enzyme that is located on the outer surface of the cells of secretory tissues [1]. It plays a central role in the metabolism of glutathione that is widely in various mammals [2]. The enzyme catalyzes the degradation of the extracellular glutathione in...

The key role of emotions in decision-making process of human beings has been highlighted recently. Our research focuses on fear-related emotions and their positive impact on the survival capabilities of human beings in case of crisis situations. In this paper, we proposed a new model of emotional contagion based on some main findings in social psychology. This model was formalized mathematicall...

Autoimmune diabetes is caused by selective loss of insulin-producing pancreatic beta-cells. The main factors directly implicated in beta-cell death are autoreactive, cytotoxic (islet-antigen specific) T-lymphocytes (CTL), and inflammatory cytokines. In this study, we have used an antigen-specific model of virally induced autoimmune diabetes to demonstrate that even high numbers of autoreactive ...

AIM Subcortical ischemic vascular dementia (SIVD) induced by chronic hypoperfusion is a common cause of vascular dementia. The aim of this study was to determine whether the protective effect of carnosine on white matter lesion after chronic cerebral hypoperfusion through suppressing astrocyte activation. METHODS Adult male mice (C57BL/6 strain) were subjected to permanent occlusion of the ri...

* Study carried out at and sponsored by Gama Filho University. Jointly sponsored by FAPERJ E-26/170.647/2001. Correspondence to: Anete Trajman. Departamento de Medicina. Universidade Gama Filho. Rua Manoel Vitorino 553, Piedade, CEP 20748-900 – Rio de Janeiro, RJ. Submitted: 4 March 2004. Accepted, after review: 5 September 2004. Background: The diagnosis of pleural tuberculosis continues to be...

Introdução: Apesar da alta taxa de contaminação, o espectro clínico e sintomatológico COVID-19 varia desde casos assintomáticos a insuficiência respiratória aguda morte. Nesse sentido, estudo patogênese do coronavírus SARS-Cov-2, especialmente as citocinas envolvidas, torna-se essencial para compreensão doença. No cenário COVID-19, estudos clínicos indicaram que certo tempo após infecção viral ...

aim : the objective of this study was to estimate the average cost of diagnosis and treatment of hepatitis c among patients based on their treatment regime, during the one course of treatment and six-month after stopping that. background : hepatitis c virus (hcv) infection is a major cause of liver-related morbidity and mortality worldwide and a major public health problem. patients and methods...

Journal of the American Chemical Society is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Communication Neuroactive Chondroitin Sulfate Glycomimetics Manish Rawat, Cristal I. Gama, John B. Matson, and Linda C. Hsieh-Wilson J. Am. Chem. Soc., 2008, 130 (10), 2959-2961• DOI: 10.1021/ja709993p • Publication Date (Web): 15 February 2008 Downloaded from...

1 Departamento de Análise Matemática, Facultade de Matemáticas, Campus Sur, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain 2 Departamento de Matemáticas, Universidad de Jaén, Ed. B3, Las Lagunillas, 23009 Jaén, Spain 3 Faculdade de Ciências da Universidade de Lisboa, Centro de Matemática e Aplicações Fundamentais, Avenida Professor Gama Pinto 2, 1649-003 Lisboa, Por...

Mathews Journal of Ophthalmology Pseudophakic Macular Edema (Irvine-Gass Syndrome): Has the Treatment Changed? Ivo Filipe Gama1 1Ophthalmology Department, Santa Maria University Hospital, Portugal. Corresponding Author: Ivo Filipe Gama, Department of Ophthalmology, Santa Maria University Hospital. Faculty of Medicine of the University of Lisbon, Lisbon, Portugal. Tel: +351 21 796 7624; Email: i...